Demographic and clinical predictors of treatment failure one year after midurethral sling surgery

Holly E. Richter, Heather J. Litman, Emily S. Lukacz, Larry T. Sirls, Leslie Rickey, Peggy Norton, Gary E. Lemack, Stephen Kraus, Pamela Moalli, Mary Pat Fitzgerald, Kimberly J. Dandreo, Liyuan Huang, John W. Kusek

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective: To identify clinical and demographic factors predictive of midurethral sling failure. Methods: Overall treatment failure was defined by one or more of the following objective outcomes: a positive stress test, positive 24-hour pad test or retreatment for stress urinary incontinence (SUI); subjective outcomes: self reported SUI by the Medical, Epidemiologic and Social Aspect of Aging questionnaire, incontinent episodes by 3-day diary, or retreatment for SUI, or a combination of these. Logistic regression models adjusting for sling type and clinical site were used to predict odds of overall treatment failure after univariable analysis. Models were also fit to compare factors associated with objective failure and subjective failure only. Results: Previous UI surgery (odds ratio [OR] 1.99, 95% confidence interval [CI] 1.14-3.47); maximum Q-tip excursion<30° (OR 1.89, 95% CI 1.16-3.05); Medical, Epidemiologic and Social Aspect of Aging questionnaire urge score per 10 points (OR 1.97, 95% CI 1.21-3.21); and pad weight per 10 g (OR 1.06, 95% CI 1.02-1.10) were predictors of overall failure. Having concomitant surgery (OR 0.44, 95% CI 0.22-0.90) was predictive of subjective failure only rather than objective failure. Age per 10 years (OR 1.48, 95% CI 1.14-1.90); Urogenital Distress Inventory score per 10 points (OR 1.09, 95% CI 1.02-1.17); pad weight per 10 g (OR 1.05, 95% CI 1.01-1.10) were predictive of objective failure compared with subjective failure only. Associations of risk factors and failure were similar independent of sling type (retropubic or transobturator). Conclusion: Twelve months after surgery, risk factors for overall and objective treatment failure were similar in women undergoing retropubic and transobturator sling procedures. This information may assist in counseling patients regarding efficacy of sling procedures and in setting expectations for women at increased odds for treatment failure.

Original languageEnglish (US)
Pages (from-to)913-921
Number of pages9
JournalObstetrics and Gynecology
Volume117
Issue number4
DOIs
StatePublished - Apr 2011

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Suburethral Slings
Treatment Failure
Odds Ratio
Demography
Confidence Intervals
Stress Urinary Incontinence
Retreatment
Logistic Models
Weights and Measures
Exercise Test
Counseling
Equipment and Supplies

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Richter, H. E., Litman, H. J., Lukacz, E. S., Sirls, L. T., Rickey, L., Norton, P., ... Kusek, J. W. (2011). Demographic and clinical predictors of treatment failure one year after midurethral sling surgery. Obstetrics and Gynecology, 117(4), 913-921. https://doi.org/10.1097/AOG.0b013e31820f3892

Demographic and clinical predictors of treatment failure one year after midurethral sling surgery. / Richter, Holly E.; Litman, Heather J.; Lukacz, Emily S.; Sirls, Larry T.; Rickey, Leslie; Norton, Peggy; Lemack, Gary E.; Kraus, Stephen; Moalli, Pamela; Fitzgerald, Mary Pat; Dandreo, Kimberly J.; Huang, Liyuan; Kusek, John W.

In: Obstetrics and Gynecology, Vol. 117, No. 4, 04.2011, p. 913-921.

Research output: Contribution to journalArticle

Richter, HE, Litman, HJ, Lukacz, ES, Sirls, LT, Rickey, L, Norton, P, Lemack, GE, Kraus, S, Moalli, P, Fitzgerald, MP, Dandreo, KJ, Huang, L & Kusek, JW 2011, 'Demographic and clinical predictors of treatment failure one year after midurethral sling surgery', Obstetrics and Gynecology, vol. 117, no. 4, pp. 913-921. https://doi.org/10.1097/AOG.0b013e31820f3892
Richter, Holly E. ; Litman, Heather J. ; Lukacz, Emily S. ; Sirls, Larry T. ; Rickey, Leslie ; Norton, Peggy ; Lemack, Gary E. ; Kraus, Stephen ; Moalli, Pamela ; Fitzgerald, Mary Pat ; Dandreo, Kimberly J. ; Huang, Liyuan ; Kusek, John W. / Demographic and clinical predictors of treatment failure one year after midurethral sling surgery. In: Obstetrics and Gynecology. 2011 ; Vol. 117, No. 4. pp. 913-921.
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AU - Rickey, Leslie

AU - Norton, Peggy

AU - Lemack, Gary E.

AU - Kraus, Stephen

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N2 - Objective: To identify clinical and demographic factors predictive of midurethral sling failure. Methods: Overall treatment failure was defined by one or more of the following objective outcomes: a positive stress test, positive 24-hour pad test or retreatment for stress urinary incontinence (SUI); subjective outcomes: self reported SUI by the Medical, Epidemiologic and Social Aspect of Aging questionnaire, incontinent episodes by 3-day diary, or retreatment for SUI, or a combination of these. Logistic regression models adjusting for sling type and clinical site were used to predict odds of overall treatment failure after univariable analysis. Models were also fit to compare factors associated with objective failure and subjective failure only. Results: Previous UI surgery (odds ratio [OR] 1.99, 95% confidence interval [CI] 1.14-3.47); maximum Q-tip excursion<30° (OR 1.89, 95% CI 1.16-3.05); Medical, Epidemiologic and Social Aspect of Aging questionnaire urge score per 10 points (OR 1.97, 95% CI 1.21-3.21); and pad weight per 10 g (OR 1.06, 95% CI 1.02-1.10) were predictors of overall failure. Having concomitant surgery (OR 0.44, 95% CI 0.22-0.90) was predictive of subjective failure only rather than objective failure. Age per 10 years (OR 1.48, 95% CI 1.14-1.90); Urogenital Distress Inventory score per 10 points (OR 1.09, 95% CI 1.02-1.17); pad weight per 10 g (OR 1.05, 95% CI 1.01-1.10) were predictive of objective failure compared with subjective failure only. Associations of risk factors and failure were similar independent of sling type (retropubic or transobturator). Conclusion: Twelve months after surgery, risk factors for overall and objective treatment failure were similar in women undergoing retropubic and transobturator sling procedures. This information may assist in counseling patients regarding efficacy of sling procedures and in setting expectations for women at increased odds for treatment failure.

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