Demonstrated and inferred metabolism associated with cytosolic lipid droplets

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Cytosolic lipid droplets were considered until recently to be rather inert particles of stored neutral lipid. Largely through proteomics is it now known that droplets are dynamic organelles and that they participate in several important metabolic reactions as well as trafficking and interorganellar communication. In this review, the role of droplets in metabolism in the yeast Saccharomyces cerevisiae, the fly Drosophila melanogaster, and several mammalian sources are discussed, particularly focusing on those reactions shared by these organisms. From proteomics and older work, it is clear that droplets are important for fatty acid and sterol biosynthesis, fatty acid activation, and lipolysis. However, many droplet-associated enzymes are predicted to span a membrane two or more times, which suggests either that droplet structure is more complex than the current model posits, or that there are tightly bound membranes, particularly derived from the endoplasmic reticulum, which account for the association of several of these proteins.

Original languageEnglish (US)
Pages (from-to)2148-2156
Number of pages9
JournalJournal of Lipid Research
Volume50
Issue number11
DOIs
StatePublished - 2009

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Metabolism
Proteomics
Fatty Acids
Lipids
Membranes
Lipolysis
Sterols
Drosophila melanogaster
Diptera
Endoplasmic Reticulum
Organelles
Saccharomyces cerevisiae
Yeasts
Communication
Yeast
Enzymes
Proteins
Biosynthesis
Lipid Droplets
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

Demonstrated and inferred metabolism associated with cytosolic lipid droplets. / Goodman, Joel M.

In: Journal of Lipid Research, Vol. 50, No. 11, 2009, p. 2148-2156.

Research output: Contribution to journalArticle

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