Demonstration of glucagon in the stomach of human fetuses

M. Ravazzola, Roger H Unger, L. Orci

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Electron microscopy using antiglucagon or antiglicentin antisera and the protein A-gold (pAg) technique revealed a population of immunoreactive cells in the gastric mucosa of human fetuses. The secretory granules of these cells showed the same ultrastructural characteristics and the same labeling pattern as pancreatic α-granules. These data demonstrate that the stomach of human fetuses contains cells with secretory granules indistinguishable by morpholigic and immunocytochemical criteria from the pancreatic A-cells.

Original languageEnglish (US)
Pages (from-to)879-882
Number of pages4
JournalDiabetes
Volume30
Issue number10
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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