Demonstration of glucagon in the stomach of human fetuses

M. Ravazzola, Roger H Unger, L. Orci

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Abstract

Electron microscopy using antiglucagon or antiglicentin antisera and the protein A-gold (pAg) technique revealed a population of immunoreactive cells in the gastric mucosa of human fetuses. The secretory granules of these cells showed the same ultrastructural characteristics and the same labeling pattern as pancreatic α-granules. These data demonstrate that the stomach of human fetuses contains cells with secretory granules indistinguishable by morpholigic and immunocytochemical criteria from the pancreatic A-cells.

Original languageEnglish (US)
Pages (from-to)879-882
Number of pages4
JournalDiabetes
Volume30
Issue number10
Publication statusPublished - 1981

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Ravazzola, M., Unger, R. H., & Orci, L. (1981). Demonstration of glucagon in the stomach of human fetuses. Diabetes, 30(10), 879-882.