Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry

Su Tang Lo, Amit Kumar, Jer Tsong Hsieh, Xiankai Sun

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Dendrimers are a class of structurally defined macromolecules featured with a central core, a low-density interior formed by repetitive branching units, and a high-density exterior terminated with surface functional groups. In contrast to their polymeric counterparts, dendrimers are nanosized and symmetrically shaped, which can be reproducibly synthesized on a large scale with monodispersity. These unique features have made dendrimers of increasing interest for drug delivery and other biomedical applications as nanoscaffold systems. Intended to address the potential use of dendrimers for the development of theranostic agents, which combines therapeutics and diagnostics in a single entity for personalized medicine, this review focuses on the reported methodologies of using dendrimer nanoscaffolds for targeted imaging and therapy of prostate cancer. Of particular interest, relevant chemistry strategies are discussed due to their important roles in the design and synthesis of diagnostic and therapeutic dendrimer-based nanoconjugates and potential theranostic agents, targeted or nontargeted. Given the developing status of nanoscaffolded theranostics, major challenges and potential hurdles are discussed along with the examples representing current advances.

Original languageEnglish (US)
Pages (from-to)793-812
Number of pages20
JournalMolecular Pharmaceutics
Volume10
Issue number3
DOIs
Publication statusPublished - 2013

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Keywords

  • dendrimer
  • drug delivery
  • molecular imaging
  • prostate cancer
  • theranostics

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Drug Discovery

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