Dendritic cells: Controllers of the immune system and a new promise for immunotherapy

Jacques Banchereau, Sophie Paczesny, Patrick Blanco, Lynda Bennett, Virginia Pascual, Joseph Fay, A. Karolina Palucka

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-α/β upon viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.

Original languageEnglish (US)
Pages (from-to)180-187
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume987
DOIs
StatePublished - Jan 1 2003

Keywords

  • Dendritic cells
  • Immunotherapy
  • Interstitial DCs
  • Langerhans cells
  • T cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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