Abstract
Dendritic epidermal T cells (DETC) in mice form part of a primitive system of epithelial-resident T cells characterized by the expression of γδ T-cell receptors (TCR). Critical attributes that characterize DETC include their highly restricted T-cell receptor gene utilization, proliferation and maturation within epidermis, a capacity to kill relevant skin-derived tumor targets, and the ability to modulate immune responses that are initiated and expressed in skin. Contemporary knowledge suggests that DETC and the related skin-directed γδ T cells found in humans play important roles in maintaining the immunologic integrity of skin.
Original language | English (US) |
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Pages (from-to) | S80-S83 |
Journal | Journal of Investigative Dermatology |
Volume | 100 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1993 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology