Dendritic epidermal T cells: lessons from mice for humans

Paul R. Bergstresser, Ponciano D Cruz, Akira Takashima

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Dendritic epidermal T cells (DETC) in mice form part of a primitive system of epithelial-resident T cells characterized by the expression of γδ T-cell receptors (TCR). Critical attributes that characterize DETC include their highly restricted T-cell receptor gene utilization, proliferation and maturation within epidermis, a capacity to kill relevant skin-derived tumor targets, and the ability to modulate immune responses that are initiated and expressed in skin. Contemporary knowledge suggests that DETC and the related skin-directed γδ T cells found in humans play important roles in maintaining the immunologic integrity of skin.

Original languageEnglish (US)
Pages (from-to)S80-S83
JournalJournal of Investigative Dermatology
Volume100
Issue number1
DOIs
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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