Denervated human skeletal muscle: MR imaging evaluation

James L. Fleckenstein, Denton Watumull, Kevin E. Conner, Marybeth Ezaki, Ralph G. Greenlee, Wilson W. Bryan, David P Chason, Robert W. Parkey, Ronald M Peshock, Phillip D. Purdy

Research output: Contribution to journalArticle

260 Citations (Scopus)

Abstract

Because determination of neurologic integrity after severe limb trauma is crucial in patient care, the authors assessed magnetic resonance (MR) imaging as a tool to map denervated motor units of skeletal muscle in patients with tramatic peripheral neuropathy. Denervation was confirmed in 22 patients with use of electromyography, surgery, or both. MR imaging was performed with moderately T1- and T2-weighted spin-echo and short-tau inversion-recovery (STIR) sequences. MR imaging was unreliable in depicting acute denervation. Muscles of patients with subacute denervation had prolonged T1 and T2, which contributed to conspicuous hyperintensity on STIR images. Chronically denervated muscles showed marked atrophy, variable changes on STIR images, and conspicuous fatty infiltration on T1-weighted images. Normal variants in motor unit anatomy were seen in denervated muscle volumes outside the expected distribution of the injured nerve. MR imaging is promising for the noninvasive mapping and monitoring of denervated muscle in subacute and chronic phases of peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalRadiology
Volume187
Issue number1
StatePublished - Apr 1993

Fingerprint

Skeletal Muscle
Denervation
Magnetic Resonance Imaging
Muscles
Peripheral Nervous System Diseases
Sequence Inversion
Electromyography
Nervous System
Atrophy
Anatomy
Patient Care
Extremities
Wounds and Injuries

Keywords

  • Extremities, injuries, 40.48, 40.491
  • Extremities, MR, 40.121413
  • Magnetic resonance (MR), tissue characterization
  • Muscles, injuries, 40.491
  • Muscles, MR, 40.121413

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Fleckenstein, J. L., Watumull, D., Conner, K. E., Ezaki, M., Greenlee, R. G., Bryan, W. W., ... Purdy, P. D. (1993). Denervated human skeletal muscle: MR imaging evaluation. Radiology, 187(1), 213-218.

Denervated human skeletal muscle : MR imaging evaluation. / Fleckenstein, James L.; Watumull, Denton; Conner, Kevin E.; Ezaki, Marybeth; Greenlee, Ralph G.; Bryan, Wilson W.; Chason, David P; Parkey, Robert W.; Peshock, Ronald M; Purdy, Phillip D.

In: Radiology, Vol. 187, No. 1, 04.1993, p. 213-218.

Research output: Contribution to journalArticle

Fleckenstein, JL, Watumull, D, Conner, KE, Ezaki, M, Greenlee, RG, Bryan, WW, Chason, DP, Parkey, RW, Peshock, RM & Purdy, PD 1993, 'Denervated human skeletal muscle: MR imaging evaluation', Radiology, vol. 187, no. 1, pp. 213-218.
Fleckenstein JL, Watumull D, Conner KE, Ezaki M, Greenlee RG, Bryan WW et al. Denervated human skeletal muscle: MR imaging evaluation. Radiology. 1993 Apr;187(1):213-218.
Fleckenstein, James L. ; Watumull, Denton ; Conner, Kevin E. ; Ezaki, Marybeth ; Greenlee, Ralph G. ; Bryan, Wilson W. ; Chason, David P ; Parkey, Robert W. ; Peshock, Ronald M ; Purdy, Phillip D. / Denervated human skeletal muscle : MR imaging evaluation. In: Radiology. 1993 ; Vol. 187, No. 1. pp. 213-218.
@article{2a0d5a0109f04a5b80208470a527961f,
title = "Denervated human skeletal muscle: MR imaging evaluation",
abstract = "Because determination of neurologic integrity after severe limb trauma is crucial in patient care, the authors assessed magnetic resonance (MR) imaging as a tool to map denervated motor units of skeletal muscle in patients with tramatic peripheral neuropathy. Denervation was confirmed in 22 patients with use of electromyography, surgery, or both. MR imaging was performed with moderately T1- and T2-weighted spin-echo and short-tau inversion-recovery (STIR) sequences. MR imaging was unreliable in depicting acute denervation. Muscles of patients with subacute denervation had prolonged T1 and T2, which contributed to conspicuous hyperintensity on STIR images. Chronically denervated muscles showed marked atrophy, variable changes on STIR images, and conspicuous fatty infiltration on T1-weighted images. Normal variants in motor unit anatomy were seen in denervated muscle volumes outside the expected distribution of the injured nerve. MR imaging is promising for the noninvasive mapping and monitoring of denervated muscle in subacute and chronic phases of peripheral neuropathy.",
keywords = "Extremities, injuries, 40.48, 40.491, Extremities, MR, 40.121413, Magnetic resonance (MR), tissue characterization, Muscles, injuries, 40.491, Muscles, MR, 40.121413",
author = "Fleckenstein, {James L.} and Denton Watumull and Conner, {Kevin E.} and Marybeth Ezaki and Greenlee, {Ralph G.} and Bryan, {Wilson W.} and Chason, {David P} and Parkey, {Robert W.} and Peshock, {Ronald M} and Purdy, {Phillip D.}",
year = "1993",
month = "4",
language = "English (US)",
volume = "187",
pages = "213--218",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Denervated human skeletal muscle

T2 - MR imaging evaluation

AU - Fleckenstein, James L.

AU - Watumull, Denton

AU - Conner, Kevin E.

AU - Ezaki, Marybeth

AU - Greenlee, Ralph G.

AU - Bryan, Wilson W.

AU - Chason, David P

AU - Parkey, Robert W.

AU - Peshock, Ronald M

AU - Purdy, Phillip D.

PY - 1993/4

Y1 - 1993/4

N2 - Because determination of neurologic integrity after severe limb trauma is crucial in patient care, the authors assessed magnetic resonance (MR) imaging as a tool to map denervated motor units of skeletal muscle in patients with tramatic peripheral neuropathy. Denervation was confirmed in 22 patients with use of electromyography, surgery, or both. MR imaging was performed with moderately T1- and T2-weighted spin-echo and short-tau inversion-recovery (STIR) sequences. MR imaging was unreliable in depicting acute denervation. Muscles of patients with subacute denervation had prolonged T1 and T2, which contributed to conspicuous hyperintensity on STIR images. Chronically denervated muscles showed marked atrophy, variable changes on STIR images, and conspicuous fatty infiltration on T1-weighted images. Normal variants in motor unit anatomy were seen in denervated muscle volumes outside the expected distribution of the injured nerve. MR imaging is promising for the noninvasive mapping and monitoring of denervated muscle in subacute and chronic phases of peripheral neuropathy.

AB - Because determination of neurologic integrity after severe limb trauma is crucial in patient care, the authors assessed magnetic resonance (MR) imaging as a tool to map denervated motor units of skeletal muscle in patients with tramatic peripheral neuropathy. Denervation was confirmed in 22 patients with use of electromyography, surgery, or both. MR imaging was performed with moderately T1- and T2-weighted spin-echo and short-tau inversion-recovery (STIR) sequences. MR imaging was unreliable in depicting acute denervation. Muscles of patients with subacute denervation had prolonged T1 and T2, which contributed to conspicuous hyperintensity on STIR images. Chronically denervated muscles showed marked atrophy, variable changes on STIR images, and conspicuous fatty infiltration on T1-weighted images. Normal variants in motor unit anatomy were seen in denervated muscle volumes outside the expected distribution of the injured nerve. MR imaging is promising for the noninvasive mapping and monitoring of denervated muscle in subacute and chronic phases of peripheral neuropathy.

KW - Extremities, injuries, 40.48, 40.491

KW - Extremities, MR, 40.121413

KW - Magnetic resonance (MR), tissue characterization

KW - Muscles, injuries, 40.491

KW - Muscles, MR, 40.121413

UR - http://www.scopus.com/inward/record.url?scp=0027450935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027450935&partnerID=8YFLogxK

M3 - Article

C2 - 8451416

AN - SCOPUS:0027450935

VL - 187

SP - 213

EP - 218

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -