Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains

Whitney G. Hartstone, Mark H. Brown, Geoffrey C. Kelly, William J. Tate, Sheng Han Kuo, Andrew J. Dwork, Elan D. Louis, Phyllis L. Faust

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. Objectives: To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls. Methods: Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm2) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Results: Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Conclusions: Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor.

Original languageEnglish (US)
Pages (from-to)995-999
Number of pages5
JournalMovement Disorders
Volume36
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • essential tremor; cerebellum; dentate neuron; stereology; pathology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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