Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains

Whitney G. Hartstone; Mark H. Brown; Geoffrey C. Kelly; William J. Tate; Sheng Han Kuo; Andrew J. Dwork; Elan D. Louis; Phyllis L. Faust

doi:10.1002/mds.28402

Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains

Whitney G. Hartstone, Mark H. Brown, Geoffrey C. Kelly, William J. Tate, Sheng Han Kuo, Andrew J. Dwork, Elan D. Louis, Phyllis L. Faust

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. Objectives: To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls. Methods: Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm²) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Results: Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Conclusions: Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor.

Original language	English (US)
Pages (from-to)	995-999
Number of pages	5
Journal	Movement Disorders
Volume	36
Issue number	4
DOIs	https://doi.org/10.1002/mds.28402
State	Published - Apr 2021

Keywords

essential tremor; cerebellum; dentate neuron; stereology; pathology

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains",

abstract = "Background: Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. Objectives: To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls. Methods: Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm2) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Results: Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Conclusions: Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor.",

keywords = "essential tremor; cerebellum; dentate neuron; stereology; pathology",

author = "Hartstone, {Whitney G.} and Brown, {Mark H.} and Kelly, {Geoffrey C.} and Tate, {William J.} and Kuo, {Sheng Han} and Dwork, {Andrew J.} and Louis, {Elan D.} and Faust, {Phyllis L.}",

note = "Publisher Copyright: {\textcopyright} 2020 International Parkinson and Movement Disorder Society",

year = "2021",

month = apr,

doi = "10.1002/mds.28402",

language = "English (US)",

volume = "36",

pages = "995--999",

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T2 - A Postmortem Study of Essential Tremor Versus Control Brains

AU - Hartstone, Whitney G.

AU - Brown, Mark H.

AU - Kelly, Geoffrey C.

AU - Tate, William J.

AU - Kuo, Sheng Han

AU - Dwork, Andrew J.

AU - Louis, Elan D.

AU - Faust, Phyllis L.

PY - 2021/4

Y1 - 2021/4

N2 - Background: Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. Objectives: To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls. Methods: Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm2) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Results: Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Conclusions: Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor.

AB - Background: Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. Objectives: To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls. Methods: Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm2) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Results: Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Conclusions: Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor.

KW - essential tremor; cerebellum; dentate neuron; stereology; pathology

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Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains

Abstract

Keywords

ASJC Scopus subject areas

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