Deoxycoformycin treatment for childhood T‐cell acute lymphoblastic leukemia early in second remission: A pediatric oncology group study

N. Winick, G. R. Buchanan, S. B. Murphy, A. Yu, J. Boyett

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

2‐Deoxycoformycin (DCF) was added to an intensive Pediatric Oncology Group protocol ( 8303) for children with T‐cell acute lymphoblastic leukemia or T‐cell lymphoblastic lymphoma in first relapse. Twenty‐seven patients received one or more courses of DCF at 15 mg/m2/day as a 3‐day continuous infusion immediately after achieving a second remission with a four‐drug reinduction regimen. Renal and neuromuscular toxicities were frequent and occasionally severe despite the provision of a source of adenosine deaminase by means of a packed red cell transfusion 1 day following the infusion of DCF. Hepatic toxicity, manifested by transaminase elevations, accompanied 62% of the courses. The median duration of the second complete re mission was 4 months (range 2‐16+ months) with only two of the 27 patients still in remission at 13 + and 16 + months. Plasma concentrations of deoxyadenosine (dAdo) and the ratio of red cell deoxyadenosine triphosphate to adenosine triphosphate (dATP:ATP) were measured prior to the DCF infusion and on day 4. A dATP:ATP ratio of 1.0 or greater was seen in two patients with acute renal failure. There was no apparent correlation between toxicity or response and the plasma dAdo concentrations. DCF administered according to this dose and schedule was excessively toxic and did not appreciably prolong the duration of the second complete remission in children with T‐cell lymphoblastic malignancies.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalMedical and Pediatric Oncology
Volume16
Issue number5
DOIs
StatePublished - 1988

Keywords

  • lymphoblastic leukemia
  • relapse
  • toxicity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Deoxycoformycin treatment for childhood T‐cell acute lymphoblastic leukemia early in second remission: A pediatric oncology group study'. Together they form a unique fingerprint.

  • Cite this