Depression and hippocampal neurogenesis

A road to remission?

Amelia J. Eisch, David Petrik

Research output: Contribution to journalArticle

268 Citations (Scopus)

Abstract

Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research - involving stress, depression, and neurogenesis - highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the "neurogenic interactome," a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives-system, region, and local regulation of neurogenesis - offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of neurogenesis in the etiology and treatment of depression.

Original languageEnglish (US)
Pages (from-to)72-75
Number of pages4
JournalScience
Volume338
Issue number6103
DOIs
StatePublished - Oct 5 2012

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Neurogenesis
Depression
Mood Disorders
Hope
Neurons
Learning Disorders
Memory Disorders
Research
Antidepressive Agents

ASJC Scopus subject areas

  • General

Cite this

Depression and hippocampal neurogenesis : A road to remission? / Eisch, Amelia J.; Petrik, David.

In: Science, Vol. 338, No. 6103, 05.10.2012, p. 72-75.

Research output: Contribution to journalArticle

Eisch, Amelia J. ; Petrik, David. / Depression and hippocampal neurogenesis : A road to remission?. In: Science. 2012 ; Vol. 338, No. 6103. pp. 72-75.
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