Depression in women: Windows of vulnerability and new insights into the link between estrogen and serotonin

Sonali Lokuge, Benicio N. Frey, Jane A. Foster, Claudio N. Soares, Meir Steiner

Research output: Contribution to journalComment/debatepeer-review

93 Scopus citations

Abstract

Objective: The purpose of this commentary is to provide an update on the research in both preclinical and clinical models regarding the cross-talk between estrogen and various serotonin molecular markers and the possible implications this may have on female-related mood disorders. Conclusions: Animal and human studies provide strong and consistent evidence suggesting that estrogen is able to regulate the serotonin pathway at various levels. The general trend that emerges is that estrogen administration increases serotonin availability by altering mRNA and protein levels of various serotonin markers and by decreasing serotonin breakdown. These effects may have direct implications on female mood disorders such as premenstrual disorders and depression during pregnancy, postpartum, and during the menopausal transition.

Original languageEnglish (US)
Pages (from-to)e1563-e1569
JournalJournal of Clinical Psychiatry
Volume72
Issue number11
DOIs
StatePublished - Nov 2011
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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