TY - JOUR
T1 - Depressive Symptoms and Incident Heart Failure Risk in the Southern Community Cohort Study
AU - Dixon, Debra D.
AU - Xu, Meng
AU - Akwo, Elvis A.
AU - Nair, Devika
AU - Schlundt, David
AU - Wang, Thomas J.
AU - Blot, William J.
AU - Lipworth, Loren
AU - Gupta, Deepak K.
N1 - Funding Information:
The Southern Community Cohort Study was supported by the National Cancer Institute (R01 CA092447, U01 CA202979). Data collection was performed by the Survey and Biospecimen Shared Resource, which is supported in part by the Vanderbilt-Ingram Cancer Center (P30 CA068485), Nashville, Tennessee, USA. Dr Dixon has received grant support from the Training in Cardiovascular Research T32 HL007411, Nashville, Tennessee, USA. Dr Nair has received support from the Agency for Healthcare Research and Quality/Patient Centered Outcomes Research Institute Learning Health Systems K12HS026395, Nashville, Tennessee, USA. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2022 American College of Cardiology Foundation
PY - 2022/4
Y1 - 2022/4
N2 - Objectives: This study aims to examine whether greater frequency of depressive symptoms associates with increased risk of incident heart failure (HF). Background: Depressive symptoms associate with adverse prognosis in patients with prevalent HF. Their association with incident HF is less studied, particularly in low-income and minority individuals. Methods: We studied 23,937 Black or White Southern Community Cohort Study participants (median age: 53 years, 70% Black, 64% women) enrolled between 2002 and 2009, without prevalent HF, receiving Centers for Medicare and Medicaid Services coverage. Cox models adjusted for traditional HF risk factors, socioeconomic and behavioral factors, social support, and antidepressant medications were used to quantify the association between depressive symptoms assessed at enrollment via the Center for Epidemiologic Studies Depression Scale (CESD-10) and incident HF ascertained from Centers for Medicare and Medicaid Services International Classification of Diseases-9th Revision (ICD-9) (code: 428.x) and ICD-10 (codes: I50, I110) codes through December 31, 2016. Results: The median CESD-10 score was 9 (IQR: 5 to 13). Over a median 11-year follow-up, 6,081 (25%) participants developed HF. The strongest correlates of CESD-10 score were antidepressant medication use, age, and socioeconomic factors, rather than traditional HF risk factors. Greater frequency of depressive symptoms associated with increased incident HF risk (per 8-U higher CESD-10 HR: 1.04; 95% CI: 1.00 to 1.09; P = 0.038) without variation by race or sex. The association between depressive symptoms and incident HF varied by antidepressant use (interaction-P = 0.03) with increased risk among individuals not taking antidepressants. Conclusions: In this high-risk, low-income, cohort of predominantly Black participants, greater frequency of depressive symptoms significantly associates with higher risk of incident HF.
AB - Objectives: This study aims to examine whether greater frequency of depressive symptoms associates with increased risk of incident heart failure (HF). Background: Depressive symptoms associate with adverse prognosis in patients with prevalent HF. Their association with incident HF is less studied, particularly in low-income and minority individuals. Methods: We studied 23,937 Black or White Southern Community Cohort Study participants (median age: 53 years, 70% Black, 64% women) enrolled between 2002 and 2009, without prevalent HF, receiving Centers for Medicare and Medicaid Services coverage. Cox models adjusted for traditional HF risk factors, socioeconomic and behavioral factors, social support, and antidepressant medications were used to quantify the association between depressive symptoms assessed at enrollment via the Center for Epidemiologic Studies Depression Scale (CESD-10) and incident HF ascertained from Centers for Medicare and Medicaid Services International Classification of Diseases-9th Revision (ICD-9) (code: 428.x) and ICD-10 (codes: I50, I110) codes through December 31, 2016. Results: The median CESD-10 score was 9 (IQR: 5 to 13). Over a median 11-year follow-up, 6,081 (25%) participants developed HF. The strongest correlates of CESD-10 score were antidepressant medication use, age, and socioeconomic factors, rather than traditional HF risk factors. Greater frequency of depressive symptoms associated with increased incident HF risk (per 8-U higher CESD-10 HR: 1.04; 95% CI: 1.00 to 1.09; P = 0.038) without variation by race or sex. The association between depressive symptoms and incident HF varied by antidepressant use (interaction-P = 0.03) with increased risk among individuals not taking antidepressants. Conclusions: In this high-risk, low-income, cohort of predominantly Black participants, greater frequency of depressive symptoms significantly associates with higher risk of incident HF.
KW - Center for Epidemiologic Studies Depression Scale
KW - depression
KW - heart failure
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U2 - 10.1016/j.jchf.2021.11.007
DO - 10.1016/j.jchf.2021.11.007
M3 - Article
C2 - 35361444
AN - SCOPUS:85126677291
VL - 10
SP - 254
EP - 262
JO - JACC: Heart Failure
JF - JACC: Heart Failure
SN - 2213-1779
IS - 4
ER -