Der(16)t(1;16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia chromosome-positive acute lymphoblastic leukemia

K. Mrozek, D. C. Arthur, C. P. Karakousis, P. R K Koduru, M. M. Le Beau, M. J. Pettenati, R. Tantravahi, E. Mrozek, C. Perez-Mesa, U. N M Rao, S. R. Frankel, F. R. Davey, C. D. Bloomfield

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

An unbalanced translocation between chromosomes 1 and 16, der(16)t(1;16), resulting in trisomy 1q and loss of genetic material from 16q, has been thus far suggested to constitute a nonrandom secondary abnormality in two types of closely related solid tumors - Ewing sarcoma and peripheral primitive neuroepithelial tumor (PNET). We report on three cases of soft tissue tumors, a myxoid liposarcoma, a PNET and a rhabdomyosarcoma, and four cases of hematologic disorders, two acute lymphoblastic leukemias (ALL), an acute mixed leukemia and a refractory anemia, that in addition to primary chromosome abnormalities displayed the presence of the der(16)t(1;16). All three cases of acute leukemia were Philadelphia (Ph) chromosome-positive and all displayed both lymphoid and myeloid antigens. Our results and review of the literature indicate that the occurrence of der(16)t(1;16) is not limited to Ewing sarcoma and PNET, but that acquisition of this abnormality may represent a more general pathway of clonal evolution in several different tumor types including Ph chromosome-positive ALL, myxoid liposarcoma, rhabdomyosarcoma, breast cancer, endometrial adenocarcinoma, myelodysplastic syndromes, acute myeloid leukemia, retinoblastoma, and Wilms' tumor.

Original languageEnglish (US)
Pages (from-to)531-538
Number of pages8
JournalInternational journal of oncology
Volume6
Issue number3
StatePublished - Jan 1 1995

Keywords

  • acute lymphoblastic leukemia
  • chromosome translocation
  • karyotyping
  • liposarcoma
  • peripheral primitive neuroepithelial tumor
  • rhabdomyosarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Der(16)t(1;16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia chromosome-positive acute lymphoblastic leukemia'. Together they form a unique fingerprint.

  • Cite this

    Mrozek, K., Arthur, D. C., Karakousis, C. P., Koduru, P. R. K., Le Beau, M. M., Pettenati, M. J., Tantravahi, R., Mrozek, E., Perez-Mesa, C., Rao, U. N. M., Frankel, S. R., Davey, F. R., & Bloomfield, C. D. (1995). Der(16)t(1;16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia chromosome-positive acute lymphoblastic leukemia. International journal of oncology, 6(3), 531-538.