Der(16)t(1;16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia chromosome-positive acute lymphoblastic leukemia

K. Mrozek, D. C. Arthur, C. P. Karakousis, P. R K Koduru, M. M. Le Beau, M. J. Pettenati, R. Tantravahi, E. Mrozek, C. Perez-Mesa, U. N M Rao, S. R. Frankel, F. R. Davey, C. D. Bloomfield

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

An unbalanced translocation between chromosomes 1 and 16, der(16)t(1;16), resulting in trisomy 1q and loss of genetic material from 16q, has been thus far suggested to constitute a nonrandom secondary abnormality in two types of closely related solid tumors - Ewing sarcoma and peripheral primitive neuroepithelial tumor (PNET). We report on three cases of soft tissue tumors, a myxoid liposarcoma, a PNET and a rhabdomyosarcoma, and four cases of hematologic disorders, two acute lymphoblastic leukemias (ALL), an acute mixed leukemia and a refractory anemia, that in addition to primary chromosome abnormalities displayed the presence of the der(16)t(1;16). All three cases of acute leukemia were Philadelphia (Ph) chromosome-positive and all displayed both lymphoid and myeloid antigens. Our results and review of the literature indicate that the occurrence of der(16)t(1;16) is not limited to Ewing sarcoma and PNET, but that acquisition of this abnormality may represent a more general pathway of clonal evolution in several different tumor types including Ph chromosome-positive ALL, myxoid liposarcoma, rhabdomyosarcoma, breast cancer, endometrial adenocarcinoma, myelodysplastic syndromes, acute myeloid leukemia, retinoblastoma, and Wilms' tumor.

Original languageEnglish (US)
Pages (from-to)531-538
Number of pages8
JournalInternational Journal of Oncology
Volume6
Issue number3
StatePublished - 1995

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Myxoid Liposarcoma
Primitive Neuroectodermal Tumors
Philadelphia Chromosome
Rhabdomyosarcoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chromosome Aberrations
Ewing's Sarcoma
Leukemia
Clonal Evolution
Refractory Anemia
Chromosomes, Human, Pair 16
Neoplasms
Wilms Tumor
Retinoblastoma
Chromosomes, Human, Pair 1
Myelodysplastic Syndromes
Trisomy
Acute Myeloid Leukemia
Adenocarcinoma
Breast Neoplasms

Keywords

  • acute lymphoblastic leukemia
  • chromosome translocation
  • karyotyping
  • liposarcoma
  • peripheral primitive neuroepithelial tumor
  • rhabdomyosarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Der(16)t(1;16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia chromosome-positive acute lymphoblastic leukemia. / Mrozek, K.; Arthur, D. C.; Karakousis, C. P.; Koduru, P. R K; Le Beau, M. M.; Pettenati, M. J.; Tantravahi, R.; Mrozek, E.; Perez-Mesa, C.; Rao, U. N M; Frankel, S. R.; Davey, F. R.; Bloomfield, C. D.

In: International Journal of Oncology, Vol. 6, No. 3, 1995, p. 531-538.

Research output: Contribution to journalArticle

Mrozek, K, Arthur, DC, Karakousis, CP, Koduru, PRK, Le Beau, MM, Pettenati, MJ, Tantravahi, R, Mrozek, E, Perez-Mesa, C, Rao, UNM, Frankel, SR, Davey, FR & Bloomfield, CD 1995, 'Der(16)t(1;16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia chromosome-positive acute lymphoblastic leukemia', International Journal of Oncology, vol. 6, no. 3, pp. 531-538.
Mrozek, K. ; Arthur, D. C. ; Karakousis, C. P. ; Koduru, P. R K ; Le Beau, M. M. ; Pettenati, M. J. ; Tantravahi, R. ; Mrozek, E. ; Perez-Mesa, C. ; Rao, U. N M ; Frankel, S. R. ; Davey, F. R. ; Bloomfield, C. D. / Der(16)t(1;16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia chromosome-positive acute lymphoblastic leukemia. In: International Journal of Oncology. 1995 ; Vol. 6, No. 3. pp. 531-538.
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abstract = "An unbalanced translocation between chromosomes 1 and 16, der(16)t(1;16), resulting in trisomy 1q and loss of genetic material from 16q, has been thus far suggested to constitute a nonrandom secondary abnormality in two types of closely related solid tumors - Ewing sarcoma and peripheral primitive neuroepithelial tumor (PNET). We report on three cases of soft tissue tumors, a myxoid liposarcoma, a PNET and a rhabdomyosarcoma, and four cases of hematologic disorders, two acute lymphoblastic leukemias (ALL), an acute mixed leukemia and a refractory anemia, that in addition to primary chromosome abnormalities displayed the presence of the der(16)t(1;16). All three cases of acute leukemia were Philadelphia (Ph) chromosome-positive and all displayed both lymphoid and myeloid antigens. Our results and review of the literature indicate that the occurrence of der(16)t(1;16) is not limited to Ewing sarcoma and PNET, but that acquisition of this abnormality may represent a more general pathway of clonal evolution in several different tumor types including Ph chromosome-positive ALL, myxoid liposarcoma, rhabdomyosarcoma, breast cancer, endometrial adenocarcinoma, myelodysplastic syndromes, acute myeloid leukemia, retinoblastoma, and Wilms' tumor.",
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AU - Arthur, D. C.

AU - Karakousis, C. P.

AU - Koduru, P. R K

AU - Le Beau, M. M.

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AU - Mrozek, E.

AU - Perez-Mesa, C.

AU - Rao, U. N M

AU - Frankel, S. R.

AU - Davey, F. R.

AU - Bloomfield, C. D.

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