Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease

Simon J. Beck, Lan Guo, Aarron Phensy, Jing Tian, Lu Wang, Neha Tandon, Esha Gauba, Lin Lu, Juan M. Pascual, Sven Kroener, Heng Du

Research output: Contribution to journalArticle

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Abstract

F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and activated mitochondrial permeability transition (mPT), defects which accompany Alzheimerâ (tm) s disease (AD). However, the molecular mechanisms that connect F1FO-ATP synthase dysfunction and AD remain unclear. Here, we observe selective loss of the oligomycin sensitivity conferring protein (OSCP) subunit of the F1FO-ATP synthase and the physical interaction of OSCP with amyloid beta (Aβ) in the brains of AD individuals and in an AD mouse model. Changes in OSCP levels are more pronounced in neuronal mitochondria. OSCP loss and its interplay with Aβ disrupt F1FO-ATP synthase, leading to reduced ATP production, elevated oxidative stress and activated mPT. The restoration of OSCP ameliorates Aβ-mediated mouse and human neuronal mitochondrial impairments and the resultant synaptic injury. Therefore, mitochondrial F1FO-ATP synthase dysfunction associated with AD progression could potentially be prevented by OSCP stabilization.

Original languageEnglish (US)
Article number11483
JournalNature Communications
Volume7
DOIs
StatePublished - May 6 2016

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Mitochondrial Proton-Translocating ATPases
Deregulation
adenosine triphosphate
Alzheimer Disease
proteins
Adenosine Triphosphate
sensitivity
mice
Permeability
permeability
phosphorylation
Mitochondria
Oxidative stress
mitochondria
Oxidative Phosphorylation
impairment
Protein Subunits
Amyloid
progressions
restoration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Beck, S. J., Guo, L., Phensy, A., Tian, J., Wang, L., Tandon, N., ... Du, H. (2016). Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. Nature Communications, 7, [11483]. https://doi.org/10.1038/ncomms11483

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. / Beck, Simon J.; Guo, Lan; Phensy, Aarron; Tian, Jing; Wang, Lu; Tandon, Neha; Gauba, Esha; Lu, Lin; Pascual, Juan M.; Kroener, Sven; Du, Heng.

In: Nature Communications, Vol. 7, 11483, 06.05.2016.

Research output: Contribution to journalArticle

Beck, SJ, Guo, L, Phensy, A, Tian, J, Wang, L, Tandon, N, Gauba, E, Lu, L, Pascual, JM, Kroener, S & Du, H 2016, 'Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease', Nature Communications, vol. 7, 11483. https://doi.org/10.1038/ncomms11483
Beck, Simon J. ; Guo, Lan ; Phensy, Aarron ; Tian, Jing ; Wang, Lu ; Tandon, Neha ; Gauba, Esha ; Lu, Lin ; Pascual, Juan M. ; Kroener, Sven ; Du, Heng. / Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. In: Nature Communications. 2016 ; Vol. 7.
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