Deriving adaptive MRF coefficients from previous normal-dose CT scan for low-dose image reconstruction via penalized weighted least-squares minimization

Hao Zhang, Hao Han, Jing Wang, Jianhua Ma, Yan Liu, William Moore, Zhengrong Liang

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Purpose: Repeated computed tomography (CT) scans are required for some clinical applications such as image-guided interventions. To optimize radiation dose utility, a normal-dose scan is often first performed to set up reference, followed by a series of low-dose scans for intervention. One common strategy to achieve the low-dose scan is to lower the x-ray tube current and exposure time (mAs) or tube voltage (kVp) setting in the scanning protocol, but the resulted image quality by the conventional filtered back-projection (FBP) method may be severely degraded due to the excessive noise. Penalized weighted least-squares (PWLS) image reconstruction has shown the potential to significantly improve the image quality from low-mAs acquisitions, where the penalty plays an important role. In this work, the authors' explore an adaptive Markov random field (MRF)-based penalty term by utilizing previous normal-dose scan to improve the subsequent low-dose scans image reconstruction. Methods: In this work, the authors employ the widely-used quadratic-form MRF as the penalty model and explore a novel idea of using the previous normal-dose scan to obtain the MRF coefficients for adaptive reconstruction of the low-dose images. In the coefficients determination, the authors further explore another novel idea of using the normal-dose scan to obtain a scale map, which describes an optimal neighborhood for the coefficients determination such that a local uniform region has a small spread of frequency spectrum and, therefore, a small MRF window, andvice versa. The proposed penalty term is incorporated into the PWLS image reconstruction framework, and the low-dose images are reconstructed via the PWLS minimization. Results: The presented adaptive MRF based PWLS algorithm was validated by physical phantom and patient data. The experimental results demonstrated that the presented algorithm is superior to the PWLS reconstruction using the conventional Gaussian MRF penalty or the edge-preserving Huber penalty and the conventional FBP method, in terms of image noise reduction and edge/detail/contrast preservation. Conclusions: This study demonstrated the feasibility and efficacy of the proposed scheme in utilizing previous normal-dose CT scan to improve the subsequent low-dose scans.

Original languageEnglish (US)
Article number041916
JournalMedical physics
Issue number4
StatePublished - Apr 2014


  • Markov random field
  • low-dose CT
  • penalized weighted least-squares
  • weighting coefficients

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


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