Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents

Amy C. Goodfriend; Tré R. Welch; Jian Wang; Kytai T. Nguyen; Romaine F. Johnson; Chet C. Xu; Surendranath R Veeram Reddy; Alan Nugent; James Richardson; Joseph M. Forbess

doi:10.1115/IMECE2015-52146

Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents

Amy C. Goodfriend, Tré R. Welch, Jian Wang, Kytai T. Nguyen, Romaine F. Johnson, Chet C. Xu, Surendranath R Veeram Reddy, Alan Nugent, James Richardson, Joseph M. Forbess

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multidrug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.

Original language	English (US)
Title of host publication	Biomedical and Biotechnology Engineering
Publisher	American Society of Mechanical Engineers (ASME)
Volume	3-2015
ISBN (Electronic)	9780791857380
DOIs	https://doi.org/10.1115/IMECE2015-52146
State	Published - 2015
Event	ASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015 - Houston, United States Duration: Nov 13 2015 → Nov 19 2015

Other

Other	ASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015
Country/Territory	United States
City	Houston
Period	11/13/15 → 11/19/15

ASJC Scopus subject areas

Mechanical Engineering

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10.1115/IMECE2015-52146

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Goodfriend, A. C., Welch, T. R., Wang, J., Nguyen, K. T., Johnson, R. F., Xu, C. C., Reddy, S. R. V., Nugent, A., Richardson, J., & Forbess, J. M. (2015). Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents. In Biomedical and Biotechnology Engineering (Vol. 3-2015). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2015-52146

Goodfriend, AC, Welch, TR, Wang, J, Nguyen, KT, Johnson, RF, Xu, CC, Reddy, SRV, Nugent, A, Richardson, J & Forbess, JM 2015, Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents. in Biomedical and Biotechnology Engineering. vol. 3-2015, American Society of Mechanical Engineers (ASME), ASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015, Houston, United States, 11/13/15. https://doi.org/10.1115/IMECE2015-52146

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abstract = "Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multidrug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.",

author = "Goodfriend, {Amy C.} and Welch, {Tr{\'e} R.} and Jian Wang and Nguyen, {Kytai T.} and Johnson, {Romaine F.} and Xu, {Chet C.} and Reddy, {Surendranath R Veeram} and Alan Nugent and James Richardson and Forbess, {Joseph M.}",

year = "2015",

doi = "10.1115/IMECE2015-52146",

language = "English (US)",

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AU - Goodfriend, Amy C.

AU - Welch, Tré R.

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AU - Nguyen, Kytai T.

AU - Johnson, Romaine F.

AU - Xu, Chet C.

AU - Reddy, Surendranath R Veeram

AU - Nugent, Alan

AU - Richardson, James

AU - Forbess, Joseph M.

PY - 2015

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N2 - Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multidrug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.

AB - Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multidrug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.

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ER -

Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents

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