TY - GEN
T1 - Design of a small animal MR compatible PET scanner
AU - Slates, Randal
AU - Cherry, Simon
AU - Boutefnouchet, Abdel
AU - Shao, Yiping
AU - Dahlbom, Magnus
AU - Farahani, Keyvan
N1 - Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 1999
Y1 - 1999
N2 - Using a combination of Monte-Carlo simulations and experimental measurements we have designed a small animal MR compatible PET (McPET) scanner for simultaneous PET and MR imaging of mice and rats in vivo. The scanner consists of one ring of 480 LSO crystals arranged in 3 layers with 160 crystals per layer. The crystal dimensions are 2 × 3 × 7.5 mm3. This was based on a target resolution of 2.5 mm and simulations showing that a depth of 7.5 mm was sufficient to provide this resolution across the desired field of view. The system diameter of 11.2 cm is large enough to accommodate the animal positioned inside a stereotactic frame. Each crystal will be coupled through 2 mm diameter optical fibers to multi-channel PMT's which reside outside the main magnetic field. Through 50 cm of optical fiber, a photopeak is clearly seen and the measured energy resolution is 25%. Prototype optical fiber connectors have been tested to increase the flexibility of the system and result in a light loss of only 6%. The proposed system will have adequate resolution and sensitivity for a number of applications in small animals and will be the first practical device for simultaneous in vivo imaging with PET and MR.
AB - Using a combination of Monte-Carlo simulations and experimental measurements we have designed a small animal MR compatible PET (McPET) scanner for simultaneous PET and MR imaging of mice and rats in vivo. The scanner consists of one ring of 480 LSO crystals arranged in 3 layers with 160 crystals per layer. The crystal dimensions are 2 × 3 × 7.5 mm3. This was based on a target resolution of 2.5 mm and simulations showing that a depth of 7.5 mm was sufficient to provide this resolution across the desired field of view. The system diameter of 11.2 cm is large enough to accommodate the animal positioned inside a stereotactic frame. Each crystal will be coupled through 2 mm diameter optical fibers to multi-channel PMT's which reside outside the main magnetic field. Through 50 cm of optical fiber, a photopeak is clearly seen and the measured energy resolution is 25%. Prototype optical fiber connectors have been tested to increase the flexibility of the system and result in a light loss of only 6%. The proposed system will have adequate resolution and sensitivity for a number of applications in small animals and will be the first practical device for simultaneous in vivo imaging with PET and MR.
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M3 - Conference contribution
AN - SCOPUS:0032596174
SN - 0780350227
T3 - IEEE Nuclear Science Symposium and Medical Imaging Conference
SP - 1268
EP - 1273
BT - IEEE Nuclear Science Symposium and Medical Imaging Conference
PB - IEEE
T2 - Proceedings of the 1998 IEEE Nuclear Science Symposium Conference Record
Y2 - 8 November 1998 through 14 November 1998
ER -