Design of a small animal MR compatible pet scanner

Randal Slates, Simon Cherry, Abdel Boutefnouchet, Yiping Shao, Magnus Dahlbom, Key Van Farahani

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Using a combination of Monte-Carlo simulations and experimental measurements we have designed a small animal MR compatible PET (McPET) scanner for simultaneous PET and MR imaging of mice and rats in vivo. The scanner consists of one ring of 480 LSO crystals arranged in 3 layers with 160 crystals per layer. The crystal dimensions are 2 × 3 times; 7.5 mm5. This was based on a target resolution of 2.5 mm and simulations showing that a depth of 7.5 mm avoided significant depth of interaction effects across the desired field of view. The system diameter of 11.2 cm is large enough to accommodate the animal positioned inside a stereotactic frame. Each crystal will be coupled through 2 mm diameter optical fibers to multi-channel PMT's which reside outside the main magnetic field. Through 50 cm of optical fiber, a photopeak is clearly seen and the measured energy resolution is 25%. Prototype optical fiber connectors have been tested to increase the flexibility of the system and result in a light loss of only 6%. The proposed system will have adequate resolution and sensitivity for a number of applications in small animals and will be the first practical device for simultaneous in vivo imaging with PET and MR.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalIEEE Transactions on Nuclear Science
Volume46
Issue number3 PART 2
DOIs
StatePublished - Dec 1 1999

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scanners
animals
Animals
Optical fibers
Crystals
optical fibers
crystals
photopeak
Imaging techniques
connectors
rats
field of view
mice
Rats
flexibility
simulation
prototypes
Magnetic fields
sensitivity
rings

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Slates, R., Cherry, S., Boutefnouchet, A., Shao, Y., Dahlbom, M., & Van Farahani, K. (1999). Design of a small animal MR compatible pet scanner. IEEE Transactions on Nuclear Science, 46(3 PART 2), 565-570. https://doi.org/10.1109/23.775580

Design of a small animal MR compatible pet scanner. / Slates, Randal; Cherry, Simon; Boutefnouchet, Abdel; Shao, Yiping; Dahlbom, Magnus; Van Farahani, Key.

In: IEEE Transactions on Nuclear Science, Vol. 46, No. 3 PART 2, 01.12.1999, p. 565-570.

Research output: Contribution to journalArticle

Slates, R, Cherry, S, Boutefnouchet, A, Shao, Y, Dahlbom, M & Van Farahani, K 1999, 'Design of a small animal MR compatible pet scanner', IEEE Transactions on Nuclear Science, vol. 46, no. 3 PART 2, pp. 565-570. https://doi.org/10.1109/23.775580
Slates R, Cherry S, Boutefnouchet A, Shao Y, Dahlbom M, Van Farahani K. Design of a small animal MR compatible pet scanner. IEEE Transactions on Nuclear Science. 1999 Dec 1;46(3 PART 2):565-570. https://doi.org/10.1109/23.775580
Slates, Randal ; Cherry, Simon ; Boutefnouchet, Abdel ; Shao, Yiping ; Dahlbom, Magnus ; Van Farahani, Key. / Design of a small animal MR compatible pet scanner. In: IEEE Transactions on Nuclear Science. 1999 ; Vol. 46, No. 3 PART 2. pp. 565-570.
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