Design studies of a high-performance onboard positron emission tomography for integrated small animal PET/CT/RT radiation research systems

Yiping Shao, Yuncheng Zhong, Xinyi Cheng, Kun Hu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The overall objective of this research is to design, develop, and evaluate an onboard high-performance Positron Emission Tomography (PET) that will be integrated into an existing CT image-guided small animal precision X-ray radiation therapy system (CT/RT). This new PET/CT/RT will enable streamlined PET/CT biology functional and organ anatomic dual-modality images to guide the therapy, and provide substantially improved beam targeting accuracy and therapy response evaluation. Both simulation and experiment studies were conducted to investigate the detector design with different resolutions, sensitivities, readout methods, and PET system configurations with different image field of view (FOV) and image performance tradeoffs. The results have shown that the 1.0 mm PET uniform image resolution and ~4% system sensitivity can be achieved within a 80 mm trans-axial and 30 mm axial image FOV. A prototype detector that has been developed and evaluated can achieve energy, coincidence timing, and depth-of-interaction resolutions at ~16%, 1.14 ns, and <3.0 mm respectively. In summary, the overall PET detector and system design studies have been successfully conducted for establishing solid technical solutions to develop the PET/CT/RT system.

Original languageEnglish (US)
Title of host publicationProceedings of the International MultiConference of Engineers and Computer Scientists 2018, IMECS 2018
EditorsOscar Castillo, David Dagan Feng, A.M. Korsunsky, Craig Douglas, S. I. Ao
PublisherNewswood Limited
ISBN (Electronic)9789881404886
StatePublished - Jan 1 2018
Event2018 International MultiConference of Engineers and Computer Scientists, IMECS 2018 - Hong Kong, Hong Kong
Duration: Mar 14 2018Mar 16 2018

Publication series

NameLecture Notes in Engineering and Computer Science
Volume2
ISSN (Print)2078-0958

Conference

Conference2018 International MultiConference of Engineers and Computer Scientists, IMECS 2018
CountryHong Kong
CityHong Kong
Period3/14/183/16/18

ASJC Scopus subject areas

  • Computer Science (miscellaneous)

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  • Cite this

    Shao, Y., Zhong, Y., Cheng, X., & Hu, K. (2018). Design studies of a high-performance onboard positron emission tomography for integrated small animal PET/CT/RT radiation research systems. In O. Castillo, D. D. Feng, A. M. Korsunsky, C. Douglas, & S. I. Ao (Eds.), Proceedings of the International MultiConference of Engineers and Computer Scientists 2018, IMECS 2018 (Lecture Notes in Engineering and Computer Science; Vol. 2). Newswood Limited.