Detection and phenotypic characterization of adult neurogenesis

H. Georg Georg Kuhn, Amelia J. Eisch, Kirsty Spalding, Daniel A. Peterson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Studies of adult neurogenesis have greatly expanded in the last decade, largely as a result of improved tools for detecting and quantifying neurogenesis. In this review,we summarize and critically evaluate detection methods for neurogenesis in mammalian and human brain tissue. Besides thymidine analog labeling, cell-cycle markers are discussed, as well as cell stage and lineage commitment markers. Use of these histological tools is critically evaluated in terms of their strengths and limitations, as well as possible artifacts. Finally, we discuss the method of radiocarbon dating for determining cell and tissue turnover in humans.

Original languageEnglish (US)
Article numbera025981
JournalCold Spring Harbor perspectives in biology
Volume8
Issue number3
DOIs
StatePublished - Mar 1 2016

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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