Detection by near-infrared spectroscopy of large lipid core plaques at culprit sites in patients with acute st-segment elevation myocardial infarction

Ryan D. Madder, James A. Goldstein, Sean P. Madden, Rishi Puri, Kathy Wolski, Michael Hendricks, Stephen T. Sum, Annapoorna Kini, Samin Sharma, David Rizik, Emmanouil S. Brilakis, Kendrick A. Shunk, John Petersen, Giora Weisz, Renu Virmani, Stephen J. Nicholls, Akiko Maehara, Gary S. Mintz, Gregg W. Stone, James E. Muller

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102 Scopus citations

Abstract

Objectives This study sought to describe near-infrared spectroscopy (NIRS) findings of culprit lesions in ST-segment elevation myocardial infarction (STEMI). Background Although autopsy studies demonstrate that most STEMI are caused by rupture of pre-existing lipid core plaque (LCP), it has not been possible to identify LCP in vivo. A novel intracoronary NIRS catheter has made it possible to detect LCP in patients. Methods We performed NIRS within the culprit vessels of 20 patients with acute STEMI and compared the STEMI culprit findings to findings in nonculprit segments of the artery and to findings in autopsy control segments. Culprit and control segments were analyzed for the maximum lipid core burden index in a 4-mm length of artery (maxLCBI 4mm). Results MaxLCBI4mm was 5.8-fold higher in STEMI culprit segments than in 87 nonculprit segments of the STEMI culprit vessel (median [interquartile range (IQR)]: 523 [445 to 821] vs. 90 [6 to 265]; p < 0.001) and 87-fold higher than in 279 coronary autopsy segments free of large LCP by histology (median [IQR]: 523 [445 to 821] vs. 6 [0 to 88]; p < 0.001).Within the STEMI culprit artery, NIRS accurately distinguished culprit from nonculprit segments (receiver-operating characteristic analysis area under the curve = 0.90). A threshold of maxLCBI4mm >400 distinguished STEMI culprit segments from specimens free of large LCP by histology (sensitivity: 85%, specificity: 98%). Conclusions The present study has demonstrated in vivo that a maxLCBI4mm >400, as detected by NIRS, is a signature of plaques causing STEMI.

Original languageEnglish (US)
Pages (from-to)838-846
Number of pages9
JournalJACC: Cardiovascular Interventions
Volume6
Issue number8
DOIs
StatePublished - Aug 1 2013

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Keywords

  • myocardial infarction near-infrared spectroscopy vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Madder, R. D., Goldstein, J. A., Madden, S. P., Puri, R., Wolski, K., Hendricks, M., Sum, S. T., Kini, A., Sharma, S., Rizik, D., Brilakis, E. S., Shunk, K. A., Petersen, J., Weisz, G., Virmani, R., Nicholls, S. J., Maehara, A., Mintz, G. S., Stone, G. W., & Muller, J. E. (2013). Detection by near-infrared spectroscopy of large lipid core plaques at culprit sites in patients with acute st-segment elevation myocardial infarction. JACC: Cardiovascular Interventions, 6(8), 838-846. https://doi.org/10.1016/j.jcin.2013.04.012