Detection of 20-hydroxyeicosatetrenoic acid in rat urine

Michal Laniado Schwartzman, Ken Omata, Faming Lin, Rama K. Bhatt, J R Falck, Nader G. Abraham

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonate metabolite of the cytochrome P450 ω hydroxylase, was detected in rat urine by gas chromatography-mass spectrometric techniques. The concentration of 20-HETE in urine from 7-week-old hypertensive and normotensive rats was 2.1 and 1.3 nM, respectively. This is the first demonstration of 20-HETE urinary excretion and thus calls attention to the possibility that 20-HETE participates in the regulation of renal function via its effect on vascular tone and ion transport processes.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume180
Issue number1
DOIs
StatePublished - Oct 15 1991

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Rats
Urine
Acids
Ion Transport
Metabolites
Mixed Function Oxygenases
Gas chromatography
Gas Chromatography
Cytochrome P-450 Enzyme System
Blood Vessels
Demonstrations
Ions
Kidney
20-hydroxy-5,8,11,14-eicosatetraenoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Detection of 20-hydroxyeicosatetrenoic acid in rat urine. / Schwartzman, Michal Laniado; Omata, Ken; Lin, Faming; Bhatt, Rama K.; Falck, J R; Abraham, Nader G.

In: Biochemical and Biophysical Research Communications, Vol. 180, No. 1, 15.10.1991, p. 445-449.

Research output: Contribution to journalArticle

Schwartzman, Michal Laniado ; Omata, Ken ; Lin, Faming ; Bhatt, Rama K. ; Falck, J R ; Abraham, Nader G. / Detection of 20-hydroxyeicosatetrenoic acid in rat urine. In: Biochemical and Biophysical Research Communications. 1991 ; Vol. 180, No. 1. pp. 445-449.
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