Abstract
20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonate metabolite of the cytochrome P450 ω hydroxylase, was detected in rat urine by gas chromatography-mass spectrometric techniques. The concentration of 20-HETE in urine from 7-week-old hypertensive and normotensive rats was 2.1 and 1.3 nM, respectively. This is the first demonstration of 20-HETE urinary excretion and thus calls attention to the possibility that 20-HETE participates in the regulation of renal function via its effect on vascular tone and ion transport processes.
Original language | English (US) |
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Pages (from-to) | 445-449 |
Number of pages | 5 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 180 |
Issue number | 1 |
DOIs | |
State | Published - Oct 15 1991 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology