Detection of 20-hydroxyeicosatetrenoic acid in rat urine

Michal Laniado Schwartzman, Ken Omata, Faming Lin, Rama K. Bhatt, J R Falck, Nader G. Abraham

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonate metabolite of the cytochrome P450 ω hydroxylase, was detected in rat urine by gas chromatography-mass spectrometric techniques. The concentration of 20-HETE in urine from 7-week-old hypertensive and normotensive rats was 2.1 and 1.3 nM, respectively. This is the first demonstration of 20-HETE urinary excretion and thus calls attention to the possibility that 20-HETE participates in the regulation of renal function via its effect on vascular tone and ion transport processes.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume180
Issue number1
DOIs
StatePublished - Oct 15 1991

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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