Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe

Kumar R. Bhushan, Preeti Misra, Fangbing Liu, Sanjeev Mathur, Robert E. Lenkinski, John V. Frangioni

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

Original languageEnglish (US)
Pages (from-to)17648-17649
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number52
DOIs
StatePublished - Dec 31 2008

Fingerprint

Calcinosis
Optical Imaging
Durapatite
Single-Photon Emission-Computed Tomography
Fluorescent Dyes
Fluorescence
Tomography
Breast Neoplasms
Hydroxyapatite
Imaging techniques
Molecules
Single Photon Emission Computed Tomography Computed Tomography

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Bhushan, K. R., Misra, P., Liu, F., Mathur, S., Lenkinski, R. E., & Frangioni, J. V. (2008). Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe. Journal of the American Chemical Society, 130(52), 17648-17649. https://doi.org/10.1021/ja807099s

Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe. / Bhushan, Kumar R.; Misra, Preeti; Liu, Fangbing; Mathur, Sanjeev; Lenkinski, Robert E.; Frangioni, John V.

In: Journal of the American Chemical Society, Vol. 130, No. 52, 31.12.2008, p. 17648-17649.

Research output: Contribution to journalArticle

Bhushan, KR, Misra, P, Liu, F, Mathur, S, Lenkinski, RE & Frangioni, JV 2008, 'Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe', Journal of the American Chemical Society, vol. 130, no. 52, pp. 17648-17649. https://doi.org/10.1021/ja807099s
Bhushan, Kumar R. ; Misra, Preeti ; Liu, Fangbing ; Mathur, Sanjeev ; Lenkinski, Robert E. ; Frangioni, John V. / Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 52. pp. 17648-17649.
@article{d121cd2ea94b4b8a8e629e17ad48ddb1,
title = "Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe",
abstract = "Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the {"}gold standard{"} by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.",
author = "Bhushan, {Kumar R.} and Preeti Misra and Fangbing Liu and Sanjeev Mathur and Lenkinski, {Robert E.} and Frangioni, {John V.}",
year = "2008",
month = "12",
day = "31",
doi = "10.1021/ja807099s",
language = "English (US)",
volume = "130",
pages = "17648--17649",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "52",

}

TY - JOUR

T1 - Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe

AU - Bhushan, Kumar R.

AU - Misra, Preeti

AU - Liu, Fangbing

AU - Mathur, Sanjeev

AU - Lenkinski, Robert E.

AU - Frangioni, John V.

PY - 2008/12/31

Y1 - 2008/12/31

N2 - Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

AB - Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

UR - http://www.scopus.com/inward/record.url?scp=58849083314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849083314&partnerID=8YFLogxK

U2 - 10.1021/ja807099s

DO - 10.1021/ja807099s

M3 - Article

C2 - 19055348

AN - SCOPUS:58849083314

VL - 130

SP - 17648

EP - 17649

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 52

ER -