Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe

Kumar R. Bhushan; Preeti Misra; Fangbing Liu; Sanjeev Mathur; Robert E. Lenkinski; John V. Frangioni

doi:10.1021/ja807099s

Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe

Kumar R. Bhushan, Preeti Misra, Fangbing Liu, Sanjeev Mathur, Robert E. Lenkinski, John V. Frangioni

Research output: Contribution to journal › Short survey › peer-review

116 Scopus citations

Abstract

Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

Original language	English (US)
Pages (from-to)	17648-17649
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	52
DOIs	https://doi.org/10.1021/ja807099s
State	Published - Dec 31 2008

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja807099s

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title = "Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe",

abstract = "Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the {"}gold standard{"} by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.",

author = "Bhushan, {Kumar R.} and Preeti Misra and Fangbing Liu and Sanjeev Mathur and Lenkinski, {Robert E.} and Frangioni, {John V.}",

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AU - Bhushan, Kumar R.

AU - Misra, Preeti

AU - Liu, Fangbing

AU - Mathur, Sanjeev

AU - Lenkinski, Robert E.

AU - Frangioni, John V.

PY - 2008/12/31

Y1 - 2008/12/31

N2 - Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

AB - Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

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Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe

Abstract

ASJC Scopus subject areas

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