Detection of dermal systemic sclerosis using noncontact optical coherence elastography

Chih Hao Liu, Yong Du, Manmohan Singh, Jiasong Li, Chen Wu, Zhaolong Han, Raksha Raghunathan, Thomas Hsu, Shezaan Noorani, M. John Hicks, Chandra Mohan, Kirill V. Larina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc is a rare disorder, but has a high mortality, particularly in last decade of life. To improve the survival rate, an accurate and early diagnosis is crucial. Currently, the modified Rodnan skin score (mRSS) is the gold standard for evaluating SSc progression based on clinical palpation at 17 sites on the body. However, this procedure can be time consuming, and the assessed score may be biased by the experience of the clinician, causing inter- and intraobserver variabilities. Moreover, the instrinsic elasticity of skin may further bias the mRSS assessment in the early stages of SSc, such as oedematous. To overcome these limitations, there is a need for a rapid, accurate, and objective assessment technique. Optical coherence elastography (OCE) is a novel, rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, we demonstrate the first use of OCE to assess the mechanical properties of control and SSc-like diseased skin non-invasively. A focused air-pulse induced an elastic wave in the skin, which was detected by a home-built OCE system. The elastic wave propagated significantly faster in SSc skin compared to healthy skin. The Young's modulus of the SSc skin was significantly higher than that of normal skin (P

Original languageEnglish (US)
Title of host publicationDynamics and Fluctuations in Biomedical Photonics XIII
PublisherSPIE
Volume9707
ISBN (Electronic)9781628419412
DOIs
StatePublished - 2016
EventDynamics and Fluctuations in Biomedical Photonics XIII Conference - San Francisco, United States
Duration: Feb 14 2016Feb 15 2016

Other

OtherDynamics and Fluctuations in Biomedical Photonics XIII Conference
CountryUnited States
CitySan Francisco
Period2/14/162/15/16

Fingerprint

Elasticity Imaging Techniques
Systemic Scleroderma
Skin
elastic waves
connective tissue
mortality
collagens
progressions
organs
micrometers
emerging
modulus of elasticity
elastic properties
spatial resolution
disorders
mechanical properties
Elastic waves
air
pulses
Tissue

Keywords

  • dermatology
  • elastic wave velocity
  • elasticity
  • optical coherence elastography
  • scleroderma

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Liu, C. H., Du, Y., Singh, M., Li, J., Wu, C., Han, Z., ... Larina, K. V. (2016). Detection of dermal systemic sclerosis using noncontact optical coherence elastography. In Dynamics and Fluctuations in Biomedical Photonics XIII (Vol. 9707). [97070J] SPIE. https://doi.org/10.1117/12.2212012

Detection of dermal systemic sclerosis using noncontact optical coherence elastography. / Liu, Chih Hao; Du, Yong; Singh, Manmohan; Li, Jiasong; Wu, Chen; Han, Zhaolong; Raghunathan, Raksha; Hsu, Thomas; Noorani, Shezaan; Hicks, M. John; Mohan, Chandra; Larina, Kirill V.

Dynamics and Fluctuations in Biomedical Photonics XIII. Vol. 9707 SPIE, 2016. 97070J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liu, CH, Du, Y, Singh, M, Li, J, Wu, C, Han, Z, Raghunathan, R, Hsu, T, Noorani, S, Hicks, MJ, Mohan, C & Larina, KV 2016, Detection of dermal systemic sclerosis using noncontact optical coherence elastography. in Dynamics and Fluctuations in Biomedical Photonics XIII. vol. 9707, 97070J, SPIE, Dynamics and Fluctuations in Biomedical Photonics XIII Conference, San Francisco, United States, 2/14/16. https://doi.org/10.1117/12.2212012
Liu CH, Du Y, Singh M, Li J, Wu C, Han Z et al. Detection of dermal systemic sclerosis using noncontact optical coherence elastography. In Dynamics and Fluctuations in Biomedical Photonics XIII. Vol. 9707. SPIE. 2016. 97070J https://doi.org/10.1117/12.2212012
Liu, Chih Hao ; Du, Yong ; Singh, Manmohan ; Li, Jiasong ; Wu, Chen ; Han, Zhaolong ; Raghunathan, Raksha ; Hsu, Thomas ; Noorani, Shezaan ; Hicks, M. John ; Mohan, Chandra ; Larina, Kirill V. / Detection of dermal systemic sclerosis using noncontact optical coherence elastography. Dynamics and Fluctuations in Biomedical Photonics XIII. Vol. 9707 SPIE, 2016.
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