Detection of lactate with a Hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia

Eric A. Mellon, Seung Cheol Lee, Stephen Pickup, Sungheon Kim, Steven C. Goldstein, Thomas F. Floyd, Harish Poptani, E. James Delikatny, Ravinder Reddy, Jerry D. Glickson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. We implemented a three-dimensional selective homonuclear multiple quantum coherence transfer version with Hadamard slice selection and two-dimensional phase encoding (Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging) on a conventional clinical MR scanner. Hadamard slice selection is explained and demonstrated in vivo. This is followed by 1-cm3 resolution lactate imaging with detection to 5-mM concentration in 20 min on a 3-T clinical scanner. An analysis of QSel gradient duration and amplitude effects on lactate and lipid signal is presented. To demonstrate clinical feasibility, a 5-min lactate scan of a patient with a non-Hodgkin's lymphoma in the superficial thigh is reported. The elevated lactate signal coincides with the T2-weighted image of this tumor. As a test of selective homonuclear multiple quantum coherence transfer sensitivity, a thigh tourniquet was applied to a normal volunteer and an increase in lactate was detected immediately after tourniquet flow constriction. In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions.

Original languageEnglish (US)
Pages (from-to)1404-1413
Number of pages10
JournalMagnetic Resonance in Medicine
Volume62
Issue number6
DOIs
StatePublished - Dec 1 2009

Fingerprint

Lactic Acid
Ischemia
Magnetic Resonance Imaging
Muscles
Neoplasms
Lipids
Tourniquets
Thigh
Constriction
Non-Hodgkin's Lymphoma
Healthy Volunteers
Magnetic Resonance Spectroscopy

Keywords

  • Blood flow occlusion
  • Hadamard encoding
  • Lactate imaging
  • Magnetic resonance spectroscopy
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Detection of lactate with a Hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner : Application to tumors and muscle ischemia. / Mellon, Eric A.; Lee, Seung Cheol; Pickup, Stephen; Kim, Sungheon; Goldstein, Steven C.; Floyd, Thomas F.; Poptani, Harish; Delikatny, E. James; Reddy, Ravinder; Glickson, Jerry D.

In: Magnetic Resonance in Medicine, Vol. 62, No. 6, 01.12.2009, p. 1404-1413.

Research output: Contribution to journalArticle

Mellon, Eric A. ; Lee, Seung Cheol ; Pickup, Stephen ; Kim, Sungheon ; Goldstein, Steven C. ; Floyd, Thomas F. ; Poptani, Harish ; Delikatny, E. James ; Reddy, Ravinder ; Glickson, Jerry D. / Detection of lactate with a Hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner : Application to tumors and muscle ischemia. In: Magnetic Resonance in Medicine. 2009 ; Vol. 62, No. 6. pp. 1404-1413.
@article{862e941b2fd94d98a7e78ed019128fa1,
title = "Detection of lactate with a Hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia",
abstract = "Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. We implemented a three-dimensional selective homonuclear multiple quantum coherence transfer version with Hadamard slice selection and two-dimensional phase encoding (Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging) on a conventional clinical MR scanner. Hadamard slice selection is explained and demonstrated in vivo. This is followed by 1-cm3 resolution lactate imaging with detection to 5-mM concentration in 20 min on a 3-T clinical scanner. An analysis of QSel gradient duration and amplitude effects on lactate and lipid signal is presented. To demonstrate clinical feasibility, a 5-min lactate scan of a patient with a non-Hodgkin's lymphoma in the superficial thigh is reported. The elevated lactate signal coincides with the T2-weighted image of this tumor. As a test of selective homonuclear multiple quantum coherence transfer sensitivity, a thigh tourniquet was applied to a normal volunteer and an increase in lactate was detected immediately after tourniquet flow constriction. In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions.",
keywords = "Blood flow occlusion, Hadamard encoding, Lactate imaging, Magnetic resonance spectroscopy, Non-Hodgkin's lymphoma",
author = "Mellon, {Eric A.} and Lee, {Seung Cheol} and Stephen Pickup and Sungheon Kim and Goldstein, {Steven C.} and Floyd, {Thomas F.} and Harish Poptani and Delikatny, {E. James} and Ravinder Reddy and Glickson, {Jerry D.}",
year = "2009",
month = "12",
day = "1",
doi = "10.1002/mrm.22141",
language = "English (US)",
volume = "62",
pages = "1404--1413",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Detection of lactate with a Hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner

T2 - Application to tumors and muscle ischemia

AU - Mellon, Eric A.

AU - Lee, Seung Cheol

AU - Pickup, Stephen

AU - Kim, Sungheon

AU - Goldstein, Steven C.

AU - Floyd, Thomas F.

AU - Poptani, Harish

AU - Delikatny, E. James

AU - Reddy, Ravinder

AU - Glickson, Jerry D.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. We implemented a three-dimensional selective homonuclear multiple quantum coherence transfer version with Hadamard slice selection and two-dimensional phase encoding (Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging) on a conventional clinical MR scanner. Hadamard slice selection is explained and demonstrated in vivo. This is followed by 1-cm3 resolution lactate imaging with detection to 5-mM concentration in 20 min on a 3-T clinical scanner. An analysis of QSel gradient duration and amplitude effects on lactate and lipid signal is presented. To demonstrate clinical feasibility, a 5-min lactate scan of a patient with a non-Hodgkin's lymphoma in the superficial thigh is reported. The elevated lactate signal coincides with the T2-weighted image of this tumor. As a test of selective homonuclear multiple quantum coherence transfer sensitivity, a thigh tourniquet was applied to a normal volunteer and an increase in lactate was detected immediately after tourniquet flow constriction. In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions.

AB - Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. We implemented a three-dimensional selective homonuclear multiple quantum coherence transfer version with Hadamard slice selection and two-dimensional phase encoding (Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging) on a conventional clinical MR scanner. Hadamard slice selection is explained and demonstrated in vivo. This is followed by 1-cm3 resolution lactate imaging with detection to 5-mM concentration in 20 min on a 3-T clinical scanner. An analysis of QSel gradient duration and amplitude effects on lactate and lipid signal is presented. To demonstrate clinical feasibility, a 5-min lactate scan of a patient with a non-Hodgkin's lymphoma in the superficial thigh is reported. The elevated lactate signal coincides with the T2-weighted image of this tumor. As a test of selective homonuclear multiple quantum coherence transfer sensitivity, a thigh tourniquet was applied to a normal volunteer and an increase in lactate was detected immediately after tourniquet flow constriction. In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions.

KW - Blood flow occlusion

KW - Hadamard encoding

KW - Lactate imaging

KW - Magnetic resonance spectroscopy

KW - Non-Hodgkin's lymphoma

UR - http://www.scopus.com/inward/record.url?scp=73149106608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73149106608&partnerID=8YFLogxK

U2 - 10.1002/mrm.22141

DO - 10.1002/mrm.22141

M3 - Article

C2 - 19785016

AN - SCOPUS:73149106608

VL - 62

SP - 1404

EP - 1413

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 6

ER -