Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo

Changho Choi, Catherine J. Ogilvie, Nikolai Malykhin, Jennifer T V Ngo, Misha A W Hartfeil, Nicholas J. Coupland

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A new proton NMR single-voxel spectral editing strategy for the rapid measurement of myo-inositol in human brain is proposed. The spectral editing detects the 4.06-ppm, weakly coupled resonance by means of selective J rewinding. An 84.6-ms-long quadruple-resonance selective 180° radiofrequency pulse, implemented within an adiabatic-refocused localization sequence, induces an in-phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g.

Original languageEnglish (US)
Pages (from-to)1536-1540
Number of pages5
JournalMagnetic resonance in medicine
Volume54
Issue number6
DOIs
StatePublished - Dec 1 2005

Keywords

  • Human brain
  • Myo-inositol (ml) 4.06 ppm resonance
  • Prefrontal cortex
  • Quadruple-resonance selective
  • Selective J rewinding

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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