Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo

Changho Choi; Catherine J. Ogilvie; Nikolai Malykhin; Jennifer T V Ngo; Misha A W Hartfeil; Nicholas J. Coupland

doi:10.1002/mrm.20688

Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo

Changho Choi, Catherine J. Ogilvie, Nikolai Malykhin, Jennifer T V Ngo, Misha A W Hartfeil, Nicholas J. Coupland

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A new proton NMR single-voxel spectral editing strategy for the rapid measurement of myo-inositol in human brain is proposed. The spectral editing detects the 4.06-ppm, weakly coupled resonance by means of selective J rewinding. An 84.6-ms-long quadruple-resonance selective 180° radiofrequency pulse, implemented within an adiabatic-refocused localization sequence, induces an in-phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g.

Original language	English (US)
Pages (from-to)	1536-1540
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	54
Issue number	6
DOIs	https://doi.org/10.1002/mrm.20688
State	Published - Dec 2005

Keywords

Human brain
Myo-inositol (ml) 4.06 ppm resonance
Prefrontal cortex
Quadruple-resonance selective
Selective J rewinding

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.20688

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title = "Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo",

abstract = "A new proton NMR single-voxel spectral editing strategy for the rapid measurement of myo-inositol in human brain is proposed. The spectral editing detects the 4.06-ppm, weakly coupled resonance by means of selective J rewinding. An 84.6-ms-long quadruple-resonance selective 180° radiofrequency pulse, implemented within an adiabatic-refocused localization sequence, induces an in-phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g.",

keywords = "Human brain, Myo-inositol (ml) 4.06 ppm resonance, Prefrontal cortex, Quadruple-resonance selective, Selective J rewinding",

author = "Changho Choi and Ogilvie, {Catherine J.} and Nikolai Malykhin and Ngo, {Jennifer T V} and Hartfeil, {Misha A W} and Coupland, {Nicholas J.}",

year = "2005",

month = dec,

doi = "10.1002/mrm.20688",

language = "English (US)",

volume = "54",

pages = "1536--1540",

journal = "Magnetic resonance in medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

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T2 - Application to human prefrontal cortex in vivo

AU - Choi, Changho

AU - Ogilvie, Catherine J.

AU - Malykhin, Nikolai

AU - Ngo, Jennifer T V

AU - Hartfeil, Misha A W

AU - Coupland, Nicholas J.

PY - 2005/12

Y1 - 2005/12

N2 - A new proton NMR single-voxel spectral editing strategy for the rapid measurement of myo-inositol in human brain is proposed. The spectral editing detects the 4.06-ppm, weakly coupled resonance by means of selective J rewinding. An 84.6-ms-long quadruple-resonance selective 180° radiofrequency pulse, implemented within an adiabatic-refocused localization sequence, induces an in-phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g.

AB - A new proton NMR single-voxel spectral editing strategy for the rapid measurement of myo-inositol in human brain is proposed. The spectral editing detects the 4.06-ppm, weakly coupled resonance by means of selective J rewinding. An 84.6-ms-long quadruple-resonance selective 180° radiofrequency pulse, implemented within an adiabatic-refocused localization sequence, induces an in-phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g.

KW - Human brain

KW - Myo-inositol (ml) 4.06 ppm resonance

KW - Prefrontal cortex

KW - Quadruple-resonance selective

KW - Selective J rewinding

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Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo

Abstract

Keywords

ASJC Scopus subject areas

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