Detection of widespread metastasis in a case of aggressive carcinoma showing thymuslike differentiation (CASTLE Disease) using 18F-FDG PET/CT

Ikponmwosa Iyamu; Jason Wachsmann; John Truelson; Dana Mathews; Fangyu Peng

doi:10.1097/RLU.0000000000000788

Detection of widespread metastasis in a case of aggressive carcinoma showing thymuslike differentiation (CASTLE Disease) using ¹⁸F-FDG PET/CT

Ikponmwosa Iyamu, Jason Wachsmann, John Truelson, Dana Mathews, Fangyu Peng

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A 30-year-old man had a diagnosis of aggressive carcinoma showing thymuslike differentiation (CASTLE disease) and underwent thyroidectomy for tumor resection and bilateral cervical lymph node dissection.Multiple hypermetabolic nodal metastases were detected in the neck and upper mediastinum with fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (¹⁸F-FDG PET/CT). The patient received radiation therapy and chemotherapy for treatment of metastases. Follow-up ¹⁸F-FDG PET/CT demonstrated resolution of several hypermetabolic lesions previously seen in the neck, but innumerable new hypermetabolic metastatic lesions were visualized. The patient died of this aggressive CASTLE disease despite treatment with surgery, radiation, and systemic chemotherapy.

Original language	English (US)
Pages (from-to)	689-691
Number of pages	3
Journal	Clinical nuclear medicine
Volume	40
Issue number	8
DOIs	https://doi.org/10.1097/RLU.0000000000000788
State	Published - Aug 2015

Keywords

CASTLE disease
Carcinoma showing thymuslike differentiation
F-FDG PET/CT
Fluorine-18-fluoro-2-deoxy-D-glucose
Positron emission tomography

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000000788

Cite this

@article{f46963631771418ca2e7f032d84603b5,

title = "Detection of widespread metastasis in a case of aggressive carcinoma showing thymuslike differentiation (CASTLE Disease) using 18F-FDG PET/CT",

abstract = "A 30-year-old man had a diagnosis of aggressive carcinoma showing thymuslike differentiation (CASTLE disease) and underwent thyroidectomy for tumor resection and bilateral cervical lymph node dissection.Multiple hypermetabolic nodal metastases were detected in the neck and upper mediastinum with fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT). The patient received radiation therapy and chemotherapy for treatment of metastases. Follow-up 18F-FDG PET/CT demonstrated resolution of several hypermetabolic lesions previously seen in the neck, but innumerable new hypermetabolic metastatic lesions were visualized. The patient died of this aggressive CASTLE disease despite treatment with surgery, radiation, and systemic chemotherapy.",

keywords = "CASTLE disease, Carcinoma showing thymuslike differentiation, F-FDG PET/CT, Fluorine-18-fluoro-2-deoxy-D-glucose, Positron emission tomography",

author = "Ikponmwosa Iyamu and Jason Wachsmann and John Truelson and Dana Mathews and Fangyu Peng",

year = "2015",

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doi = "10.1097/RLU.0000000000000788",

language = "English (US)",

volume = "40",

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journal = "Clinical nuclear medicine",

issn = "0363-9762",

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T1 - Detection of widespread metastasis in a case of aggressive carcinoma showing thymuslike differentiation (CASTLE Disease) using 18F-FDG PET/CT

AU - Iyamu, Ikponmwosa

AU - Wachsmann, Jason

AU - Truelson, John

AU - Mathews, Dana

AU - Peng, Fangyu

PY - 2015/8

Y1 - 2015/8

N2 - A 30-year-old man had a diagnosis of aggressive carcinoma showing thymuslike differentiation (CASTLE disease) and underwent thyroidectomy for tumor resection and bilateral cervical lymph node dissection.Multiple hypermetabolic nodal metastases were detected in the neck and upper mediastinum with fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT). The patient received radiation therapy and chemotherapy for treatment of metastases. Follow-up 18F-FDG PET/CT demonstrated resolution of several hypermetabolic lesions previously seen in the neck, but innumerable new hypermetabolic metastatic lesions were visualized. The patient died of this aggressive CASTLE disease despite treatment with surgery, radiation, and systemic chemotherapy.

AB - A 30-year-old man had a diagnosis of aggressive carcinoma showing thymuslike differentiation (CASTLE disease) and underwent thyroidectomy for tumor resection and bilateral cervical lymph node dissection.Multiple hypermetabolic nodal metastases were detected in the neck and upper mediastinum with fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT). The patient received radiation therapy and chemotherapy for treatment of metastases. Follow-up 18F-FDG PET/CT demonstrated resolution of several hypermetabolic lesions previously seen in the neck, but innumerable new hypermetabolic metastatic lesions were visualized. The patient died of this aggressive CASTLE disease despite treatment with surgery, radiation, and systemic chemotherapy.

KW - CASTLE disease

KW - Carcinoma showing thymuslike differentiation

KW - F-FDG PET/CT

KW - Fluorine-18-fluoro-2-deoxy-D-glucose

KW - Positron emission tomography

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