Detection of Widespread Metastasis in a Case of Aggressive Carcinoma Showing Thymuslike Differentiation (CASTLE Disease) Using 18F-FDG PET/CT

Ikponmwosa Iyamu, Jason Wachsmann, John Truelson, Dana Mathews, Fangyu Peng

Research output: Contribution to journalArticle

3 Scopus citations


A 30-year-old man had a diagnosis of aggressive carcinoma showing thymuslike differentiation (CASTLE disease) and underwent thyroidectomy for tumor resection and bilateral cervical lymph node dissection. Multiple hypermetabolic nodal metastases were detected in the neck and upper mediastinum with fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography ((18)F-FDG PET/CT). The patient received radiation therapy and chemotherapy for treatment of metastases. Follow-up (18)F-FDG PET/CT demonstrated resolution of several hypermetabolic lesions previously seen in the neck, but innumerable new hypermetabolic metastatic lesions were visualized. The patient died of this aggressive CASTLE disease despite treatment with surgery, radiation, and systemic chemotherapy.

Original languageEnglish (US)
Pages (from-to)689-691
Number of pages3
JournalClinical Nuclear Medicine
Issue number8
StatePublished - Aug 1 2015


ASJC Scopus subject areas

  • Medicine(all)

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