Determinants of endothelial function in human immunodeficiency virus infection: a complex interplay among therapy, disease, and host factors.

Kristin E. Mondy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the era of highly active antiretroviral therapy (HAART), human immunodeficiency virus (HIV) infection has become a chronic disease in which patients may develop significant metabolic complications and risk factors for cardiovascular disease (CVD), including insulin resistance, visceral fat deposition, and increases in atherogenic cholesterol and triglyceride levels. Epidemiologic studies have found that persons infected with HIV are likely to be at higher risk for premature CVD compared with the general population, and clinical studies examining endothelial function in HIV-infected cohorts have supported such conclusions. The mechanisms underlying the regulation of endothelial function in HIV-infected persons appear to be multifactorial, including direct effects of HIV on the endothelium, indirect effects of HIV on lipids and inflammatory cytokines, HAART-related effects, and traditional/host factors. Better understanding of these processes can lead to improved strategies for the long-term management of HIV infection.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalJournal of the CardioMetabolic Syndrome
Volume3
Issue number2
StatePublished - Mar 2008

Fingerprint

Virus Diseases
HIV
Highly Active Antiretroviral Therapy
Therapeutics
Cardiovascular Diseases
Intra-Abdominal Fat
Endothelium
Insulin Resistance
Epidemiologic Studies
Triglycerides
Chronic Disease
Cholesterol
Cytokines
Lipids
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

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abstract = "In the era of highly active antiretroviral therapy (HAART), human immunodeficiency virus (HIV) infection has become a chronic disease in which patients may develop significant metabolic complications and risk factors for cardiovascular disease (CVD), including insulin resistance, visceral fat deposition, and increases in atherogenic cholesterol and triglyceride levels. Epidemiologic studies have found that persons infected with HIV are likely to be at higher risk for premature CVD compared with the general population, and clinical studies examining endothelial function in HIV-infected cohorts have supported such conclusions. The mechanisms underlying the regulation of endothelial function in HIV-infected persons appear to be multifactorial, including direct effects of HIV on the endothelium, indirect effects of HIV on lipids and inflammatory cytokines, HAART-related effects, and traditional/host factors. Better understanding of these processes can lead to improved strategies for the long-term management of HIV infection.",
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