Determinants of eosinophil survival and apoptotic cell death

Research output: Contribution to journalArticle

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Abstract

Eosinophils (Eos) are potent inflammatory cells and abundantly present in the sputum and lung of patients with allergic asthma. During both transit to and residence in the lung, Eos contact prosurvival cytokines, particularly IL-3, IL-5 and GM-CSF, that attenuate cell death. Cytokine signaling modulates the expression and function of a number of intracellular pro- and anti-apoptotic molecules. Both intrinsic mitochondrial and extrinsic receptor-mediated pathways are affected. This article discusses the fundamental role of the extracellular and intracellular molecules that initiate and control survival decisions by human Eos and highlights the role of the cis-trans isomerase, Pin1 in controlling these processes.

Original languageEnglish (US)
Pages (from-to)224-234
Number of pages11
JournalApoptosis
Volume20
Issue number2
DOIs
StatePublished - Feb 2015

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Keywords

  • Apoptosis
  • Asthma
  • Cytokines
  • Eosinophils
  • Prolyl-isomerase Pin1
  • Signal transduction

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Cancer Research

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