Abstract
Two analogs of sildenafil and vardenafil in food were detected by column liquid chromatography (LC) with a photodiode array detector. They were isolated by preparative LC; their structures were established by mass spectrometry and nuclear magnetic resonance spectrometry. One analog was found to be methisosildenafil (compound A), 5-(5-(3,5-dimethylpiperazin-1-ylsulfonyl)-2- ethoxyphenyl)-1 -methyl-3-propyl-1 H-pyrazolo[4,3-d]-pyrimidin-7(6H)-one. It is a sildenafil analog with a dimethylpiperazine ring substituted for the methylpiperazine group. The second analog, hydroxyvardenafil (compound B) is reported for the first time in this study. Hydroxyvardenafil's International Union of Pure and Applied Chemistry name is 2-(2-ethoxy-5-(4-(2-hydroxyethyl)- piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[1,5-f][1,2,4] triazin-4(3H)-one. The novel vardenafil analog has a hydroxyl group added to the ethylpiperazine group.
Original language | English (US) |
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Pages (from-to) | 580-588 |
Number of pages | 9 |
Journal | Journal of AOAC International |
Volume | 91 |
Issue number | 3 |
DOIs | |
State | Published - 2008 |
ASJC Scopus subject areas
- Analytical Chemistry
- Food Science
- Environmental Chemistry
- Agronomy and Crop Science
- Pharmacology