Determination of biogenic amines in Bokbunja (Rubus coreanus Miq.) wines using a novel ultra-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry

Shaodong Jia; Yun Pyo Kang; Jeong Hill Park; Jeongmi Lee; Sung Won Kwon

doi:10.1016/j.foodchem.2011.11.069

Determination of biogenic amines in Bokbunja (Rubus coreanus Miq.) wines using a novel ultra-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry

Shaodong Jia, Yun Pyo Kang, Jeong Hill Park, Jeongmi Lee, Sung Won Kwon

Physiology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A rapid and novel ultra-performance liquid chromatography/quadrupole-time of flight mass spectrometry (UPLC/Q-TOFMS) method was developed for the detection of seven biogenic amines in Korean Bokbunja wines. The biogenic amines were pre-column derivatised with dansyl chloride and subsequently extracted by a solid phase extraction cartridge. For the analysis, the dansylated amines were separated on an Acquity™ UPLC column and detected with a micrOTOF-Q II mass spectrometer. The method was validated in terms of linearity, sensitivity, precision and recovery. The coefficient of determination (R ²) was higher than 0.994 for all calibration curves. The limit of detection was between 3 and 15 ng/mL. The intra- and inter-day precisions were below 5.0% and 10.7%, respectively. The proposed method was successfully applied for the biogenic amine analysis of 18 commercially available Bokbunja wines. None of the biogenic amine levels found in Bokbunja wines surpassed the toxic levels reported in the literature.

Original language	English (US)
Pages (from-to)	1185-1190
Number of pages	6
Journal	Food Chemistry
Volume	132
Issue number	3
DOIs	https://doi.org/10.1016/j.foodchem.2011.11.069
State	Published - Jun 1 2012

Keywords

Biogenic amine
Bokbunja wine
Dansyl chloride
Q-TOFMS
UPLC

ASJC Scopus subject areas

Analytical Chemistry
Food Science

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10.1016/j.foodchem.2011.11.069

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Determination of biogenic amines in Bokbunja (Rubus coreanus Miq.) wines using a novel ultra-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry. / Jia, Shaodong; Kang, Yun Pyo; Park, Jeong Hill; Lee, Jeongmi; Kwon, Sung Won.

In: Food Chemistry, Vol. 132, No. 3, 01.06.2012, p. 1185-1190.

Research output: Contribution to journal › Article › peer-review

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abstract = "A rapid and novel ultra-performance liquid chromatography/quadrupole-time of flight mass spectrometry (UPLC/Q-TOFMS) method was developed for the detection of seven biogenic amines in Korean Bokbunja wines. The biogenic amines were pre-column derivatised with dansyl chloride and subsequently extracted by a solid phase extraction cartridge. For the analysis, the dansylated amines were separated on an Acquity{\texttrademark} UPLC column and detected with a micrOTOF-Q II mass spectrometer. The method was validated in terms of linearity, sensitivity, precision and recovery. The coefficient of determination (R 2) was higher than 0.994 for all calibration curves. The limit of detection was between 3 and 15 ng/mL. The intra- and inter-day precisions were below 5.0% and 10.7%, respectively. The proposed method was successfully applied for the biogenic amine analysis of 18 commercially available Bokbunja wines. None of the biogenic amine levels found in Bokbunja wines surpassed the toxic levels reported in the literature.",

keywords = "Biogenic amine, Bokbunja wine, Dansyl chloride, Q-TOFMS, UPLC",

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note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011-0005831 ) and was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MEST) (No. 2011-0030635 ).",

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AU - Lee, Jeongmi

AU - Kwon, Sung Won

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011-0005831 ) and was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MEST) (No. 2011-0030635 ).

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Determination of biogenic amines in Bokbunja (Rubus coreanus Miq.) wines using a novel ultra-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry

Abstract

Keywords

ASJC Scopus subject areas

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