Determination of global function and regional mechanics of dynamic cardiomyoplasty using magnetic resonance imaging

Sorin V. Pusca, James J. Pilla, Aaron S. Blom, Himanshu J. Patel, Lawrence Dougherty, Qing Yuan, Victor A. Ferrari, Leon Axel, Michael A. Acker

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This study used tissue tagged magnetic resonance (MR) to assess regional strain and generate pressure-volume (PV) loops in a canine model of cardiomyoplasty (CMP). Three dogs with rapid ventricular pacing induced heart failure underwent dynamic CMP chronic cardiac assistance for 1 year. At the end of the study period, we performed a MR study with the myostimulator `on' and `off' and recording of left ventricular (LV) pressure. We determined the short axis displacement (D) and maximal and minimal principal strains (λ1 and λ2) by quantitative two-dimensional regional spatial modulation of magnetization visualization utility image analysis. LP PV loops were generated by combining the LV volume data from the MR images with the LV pressure recorded during imaging. Muscle stimulation produced a leftward shift of the LV PV loops in two of the three dogs, and an increase in LV peak pressure and dp/dt max. In contrast, short axis λ1 and λ2 did not change significantly (p = NS). D increased significantly in the anterolateral, posterolateral, and posteroseptal regions (p<0.05) but did not change for the septal region (p = NS). Flap stimulation augments LV function in the absence of short axis strain change; this suggests that dynamic CMP exerts its main action along the long axis of the heart.

Original languageEnglish (US)
Pages (from-to)M491-M495
JournalASAIO Journal
Issue number5
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Determination of global function and regional mechanics of dynamic cardiomyoplasty using magnetic resonance imaging'. Together they form a unique fingerprint.

Cite this