TY - GEN
T1 - Determination of lesion size as function of HIFU sonication time using MRI monitored HIFU ablations
AU - Dasgupta, Subhashish
AU - Wansapura, Janaka
AU - Hariharan, Prasanna
AU - Pratt, Ron
AU - Witte, David
AU - Myers, Matthew R.
AU - Banerjee, Rupak K.
PY - 2009
Y1 - 2009
N2 - The purpose of this study is to determine the dependence of the size of the thermal lesion on sonication time in an ex-vivo porcine liver sample during simulated High Intensity Focused Ultrasound (HIFU) tissue ablation. MRI guided HIFU ablations were performed on a freshly excised porcine liver sample at 70 W acoustic power. The size of the lesion (ablated zone) was measured at sonication times, 20 s, 30 s and 40 s. Numerical calculations were performed to validate the experimental lesion size. Also, a histology study of the ablated liver sample was performed to confirm cell necrosis within the ablated zones. It was found that the HIFU induced lesion size is strongly dependant on sonication time and lesion size almost doubles (increases from 0.368 to 0.715 cm2) as sonication time increases from 20s to 40s. The area of lesions, determined experimentally, agreed within 5% with results of numerical calculations.
AB - The purpose of this study is to determine the dependence of the size of the thermal lesion on sonication time in an ex-vivo porcine liver sample during simulated High Intensity Focused Ultrasound (HIFU) tissue ablation. MRI guided HIFU ablations were performed on a freshly excised porcine liver sample at 70 W acoustic power. The size of the lesion (ablated zone) was measured at sonication times, 20 s, 30 s and 40 s. Numerical calculations were performed to validate the experimental lesion size. Also, a histology study of the ablated liver sample was performed to confirm cell necrosis within the ablated zones. It was found that the HIFU induced lesion size is strongly dependant on sonication time and lesion size almost doubles (increases from 0.368 to 0.715 cm2) as sonication time increases from 20s to 40s. The area of lesions, determined experimentally, agreed within 5% with results of numerical calculations.
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U2 - 10.1115/SBC2009-205163
DO - 10.1115/SBC2009-205163
M3 - Conference contribution
AN - SCOPUS:77953730379
SN - 9780791848913
T3 - Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
SP - 971
EP - 972
BT - Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
T2 - 11th ASME Summer Bioengineering Conference, SBC2009
Y2 - 17 June 2009 through 21 June 2009
ER -