Determination of lesion size as function of HIFU sonication time using MRI monitored HIFU ablations

Subhashish Dasgupta, Janaka Wansapura, Prasanna Hariharan, Ron Pratt, David Witte, Matthew R. Myers, Rupak K. Banerjee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study is to determine the dependence of the size of the thermal lesion on sonication time in an ex-vivo porcine liver sample during simulated High Intensity Focused Ultrasound (HIFU) tissue ablation. MRI guided HIFU ablations were performed on a freshly excised porcine liver sample at 70 W acoustic power. The size of the lesion (ablated zone) was measured at sonication times, 20 s, 30 s and 40 s. Numerical calculations were performed to validate the experimental lesion size. Also, a histology study of the ablated liver sample was performed to confirm cell necrosis within the ablated zones. It was found that the HIFU induced lesion size is strongly dependant on sonication time and lesion size almost doubles (increases from 0.368 to 0.715 cm2) as sonication time increases from 20s to 40s. The area of lesions, determined experimentally, agreed within 5% with results of numerical calculations.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
Pages971-972
Number of pages2
EditionPART B
DOIs
StatePublished - 2009
Externally publishedYes
Event11th ASME Summer Bioengineering Conference, SBC2009 - Lake Tahoe, CA, United States
Duration: Jun 17 2009Jun 21 2009

Publication series

NameProceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
NumberPART B

Other

Other11th ASME Summer Bioengineering Conference, SBC2009
CountryUnited States
CityLake Tahoe, CA
Period6/17/096/21/09

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Fingerprint Dive into the research topics of 'Determination of lesion size as function of HIFU sonication time using MRI monitored HIFU ablations'. Together they form a unique fingerprint.

Cite this