Determination of reduced scattering coefficient of biological tissue from a needle-like probe

Maureen Johns; Cole A. Giller; Dwighl C. German; Hanli Liu

doi:10.1364/OPEX.13.004828

Determination of reduced scattering coefficient of biological tissue from a needle-like probe

Maureen Johns, Cole A. Giller, Dwighl C. German, Hanli Liu

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Detection of interactions between light and tissue can be used to characterize the optical properties of the tissue. The purpose of this paper is to develop an algorithm that determines the reduced scattering coefficient (μ_s') of tissues from a single optical reflectance spectrum measured with a small source-detector separation. A qualitative relationship between μ_s' and optical reflectance was developed using both Monte Carlo simulations and empirical tissue calibrations for each of two fiber optic probes with 400-μm and 100-μm fibers. Optical reflectance measurements, using a standard frequency-domain oximeter, were performed to validate the calculated μ_s' values. The algorithm was useful for determining μ_s' values of in vivo human fingers and rat brain tissues.

Original language	English (US)
Pages (from-to)	4828-4842
Number of pages	15
Journal	Optics Express
Volume	13
Issue number	13
DOIs	https://doi.org/10.1364/OPEX.13.004828
State	Published - Jun 27 2005

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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title = "Determination of reduced scattering coefficient of biological tissue from a needle-like probe",

abstract = "Detection of interactions between light and tissue can be used to characterize the optical properties of the tissue. The purpose of this paper is to develop an algorithm that determines the reduced scattering coefficient (μs') of tissues from a single optical reflectance spectrum measured with a small source-detector separation. A qualitative relationship between μs' and optical reflectance was developed using both Monte Carlo simulations and empirical tissue calibrations for each of two fiber optic probes with 400-μm and 100-μm fibers. Optical reflectance measurements, using a standard frequency-domain oximeter, were performed to validate the calculated μs' values. The algorithm was useful for determining μs' values of in vivo human fingers and rat brain tissues.",

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AU - Johns, Maureen

AU - Giller, Cole A.

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AU - Liu, Hanli

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AB - Detection of interactions between light and tissue can be used to characterize the optical properties of the tissue. The purpose of this paper is to develop an algorithm that determines the reduced scattering coefficient (μs') of tissues from a single optical reflectance spectrum measured with a small source-detector separation. A qualitative relationship between μs' and optical reflectance was developed using both Monte Carlo simulations and empirical tissue calibrations for each of two fiber optic probes with 400-μm and 100-μm fibers. Optical reflectance measurements, using a standard frequency-domain oximeter, were performed to validate the calculated μs' values. The algorithm was useful for determining μs' values of in vivo human fingers and rat brain tissues.

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Determination of reduced scattering coefficient of biological tissue from a needle-like probe

Abstract

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