Determination of stone-forming risk by measuring crystal formation in whole urine with gel model

Claus Roehrborn, Hans Joachim Schneider, Erwin W. Rugendorff

Research output: Contribution to journalArticle

3 Scopus citations


A simple and easy-to-handle method for measuring calcium oxalate crystal formation in whole urine samples using a gel system is described. To prove reliability of the method, the crystallization-inhibiting effect of a number of well-known, so-called inhibitors of crystallization is demonstrated. In testing urine samples from recurrent stone formers and healthy controls, we found a significant difference in the inhibitor index, the stone formers producing more crystals than the controls. Experiments in test persons with oral loading of magnesium compounds and alkalinizing substances suggest that this effect is probably caused by alteration of the urine composition, e.g., a lower excretion of inhibitors by the stone formers.

Original languageEnglish (US)
Pages (from-to)531-536
Number of pages6
Issue number6
StatePublished - Jun 1986


ASJC Scopus subject areas

  • Urology

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