Detrimental effect of mitochondria on hybrid cell survival

Lamont G. Weide, Mike A. Clark, Claud S. Rupert, Jerry W. Shay

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A genetic technique has been developed for isolating nuclear hybrids which are products of fusion between karyoplasts and whole cells. Nuclear hybrids have a greatly reduced mitochondrial component obtained from the nuclear donor and exhibit differences when compared to the corresponding whole-cell hybrids, such as better long-term survival and accelerated chromosome segregation. These results suggest that divergent mitochondria in a cell-fusion product may have adverse effects on survival.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalSomatic Cell Genetics
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Genetics

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