Detrimental effect of mitochondria on hybrid cell survival

Lamont G. Weide; Mike A. Clark; Claud S. Rupert; Jerry W. Shay

doi:10.1007/BF01538647

Detrimental effect of mitochondria on hybrid cell survival

Lamont G. Weide, Mike A. Clark, Claud S. Rupert, Jerry W. Shay

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A genetic technique has been developed for isolating nuclear hybrids which are products of fusion between karyoplasts and whole cells. Nuclear hybrids have a greatly reduced mitochondrial component obtained from the nuclear donor and exhibit differences when compared to the corresponding whole-cell hybrids, such as better long-term survival and accelerated chromosome segregation. These results suggest that divergent mitochondria in a cell-fusion product may have adverse effects on survival.

Original language	English (US)
Pages (from-to)	15-21
Number of pages	7
Journal	Somatic Cell Genetics
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/BF01538647
State	Published - Jan 1982

ASJC Scopus subject areas

Genetics

Access to Document

10.1007/BF01538647

Cite this

@article{502847f4c64c40a3932b16406c6c347b,

title = "Detrimental effect of mitochondria on hybrid cell survival",

abstract = "A genetic technique has been developed for isolating nuclear hybrids which are products of fusion between karyoplasts and whole cells. Nuclear hybrids have a greatly reduced mitochondrial component obtained from the nuclear donor and exhibit differences when compared to the corresponding whole-cell hybrids, such as better long-term survival and accelerated chromosome segregation. These results suggest that divergent mitochondria in a cell-fusion product may have adverse effects on survival.",

author = "Weide, {Lamont G.} and Clark, {Mike A.} and Rupert, {Claud S.} and Shay, {Jerry W.}",

year = "1982",

month = jan,

doi = "10.1007/BF01538647",

language = "English (US)",

volume = "8",

pages = "15--21",

journal = "Somatic Cell Genetics",

issn = "0098-0366",

publisher = "Plenum Publishers",

number = "1",

}

TY - JOUR

T1 - Detrimental effect of mitochondria on hybrid cell survival

AU - Weide, Lamont G.

AU - Clark, Mike A.

AU - Rupert, Claud S.

AU - Shay, Jerry W.

PY - 1982/1

Y1 - 1982/1

N2 - A genetic technique has been developed for isolating nuclear hybrids which are products of fusion between karyoplasts and whole cells. Nuclear hybrids have a greatly reduced mitochondrial component obtained from the nuclear donor and exhibit differences when compared to the corresponding whole-cell hybrids, such as better long-term survival and accelerated chromosome segregation. These results suggest that divergent mitochondria in a cell-fusion product may have adverse effects on survival.

AB - A genetic technique has been developed for isolating nuclear hybrids which are products of fusion between karyoplasts and whole cells. Nuclear hybrids have a greatly reduced mitochondrial component obtained from the nuclear donor and exhibit differences when compared to the corresponding whole-cell hybrids, such as better long-term survival and accelerated chromosome segregation. These results suggest that divergent mitochondria in a cell-fusion product may have adverse effects on survival.

UR - http://www.scopus.com/inward/record.url?scp=0020001074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020001074&partnerID=8YFLogxK

U2 - 10.1007/BF01538647

DO - 10.1007/BF01538647

M3 - Article

C2 - 7101102

AN - SCOPUS:0020001074

SN - 0098-0366

VL - 8

SP - 15

EP - 21

JO - Somatic Cell Genetics

JF - Somatic Cell Genetics

IS - 1

ER -

Detrimental effect of mitochondria on hybrid cell survival

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this