Deuterium metabolic imaging of the human brain in vivo at 7 T

Eulalia Serés Roig, Henk M. De Feyter, Terence W. Nixon, Loreen Ruhm, Anton V. Nikulin, Klaus Scheffler, Nikolai I. Avdievich, Anke Henning, Robin A. de Graaf

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To explore the potential of deuterium metabolic imaging (DMI) in the human brain in vivo at 7 T, using a multi-element deuterium (2H) RF coil for 3D volume coverage. Methods: 1H-MR images and localized 2H MR spectra were acquired in vivo in the human brain of 3 healthy subjects to generate DMI maps of 2H-labeled water, glucose, and glutamate/glutamine (Glx). In addition, non-localized 2H-MR spectra were acquired both in vivo and in vitro to determine T1 and T2 relaxation times of deuterated metabolites at 7 T. The performance of the 2H coil was assessed through numeric simulations and experimentally acquired B1+ maps. Results: 3D DMI maps covering the entire human brain in vivo were obtained from well-resolved deuterated (2H) metabolite resonances of water, glucose, and Glx. The T1 and T2 relaxation times were consistent with those reported at adjacent field strengths. Experimental B1+ maps were in good agreement with simulations, indicating efficient and homogeneous B1+ transmission and low RF power deposition for 2H, consistent with a similar array coil design reported at 9.4 T. Conclusion: Here, we have demonstrated the successful implementation of 3D DMI in the human brain in vivo at 7 T. The spatial and temporal nominal resolutions achieved at 7 T (i.e., 2.7 mL in 28 min, respectively) were close to those achieved at 9.4 T and greatly outperformed DMI at lower magnetic fields. DMI at 7 T and beyond has clear potential in applications dealing with small brain lesions.

Original languageEnglish (US)
JournalMagnetic resonance in medicine
DOIs
StateAccepted/In press - 2022

Keywords

  • 7 Tesla (7 T)
  • brain energy metabolism
  • deuterium (H)
  • deuterium metabolic imaging (DMI)
  • glucose
  • glutamate/glutamine (Glx)
  • human brain
  • water

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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