TY - GEN
T1 - Development and characterization of dual-release poly(D,L-lactide-co- glycolide) millirods for tumor treatment
AU - Weinberg, Brent
AU - Qian, Feng
AU - Gao, Jinming
PY - 2006
Y1 - 2006
N2 - In recent years, minimally invasive treatments of solid tumors, such as image-guided radiofrequency (RF) ablation, have emerged as a powerful alternative therapy to surgery for patients with unresectable tumors. One major limitation of RF ablation is frequent recurrence of tumors due to incomplete destruction of cancerous cells at the tumor boundary. Biodegradable polymer millirods, composed of poly(D,L-lactide-co-glycolide) (PLGA) and impregnated with anti-cancer agents, have been designed to be implanted in tumors after RF ablation to deliver drugs to the surrounding tissue and kill the remaining tumor cells. By tailoring device design, it is possible to create dual-release polymer implants that incorporate both a burst release to rapidly raise the surrounding tissue drug concentrations as well as a sustained release to maintain those drug concentrations for an extended period of time. Combination of RF ablation with local drug therapy will provide a minimally invasive paradigm for the effective treatment of solid tumors.
AB - In recent years, minimally invasive treatments of solid tumors, such as image-guided radiofrequency (RF) ablation, have emerged as a powerful alternative therapy to surgery for patients with unresectable tumors. One major limitation of RF ablation is frequent recurrence of tumors due to incomplete destruction of cancerous cells at the tumor boundary. Biodegradable polymer millirods, composed of poly(D,L-lactide-co-glycolide) (PLGA) and impregnated with anti-cancer agents, have been designed to be implanted in tumors after RF ablation to deliver drugs to the surrounding tissue and kill the remaining tumor cells. By tailoring device design, it is possible to create dual-release polymer implants that incorporate both a burst release to rapidly raise the surrounding tissue drug concentrations as well as a sustained release to maintain those drug concentrations for an extended period of time. Combination of RF ablation with local drug therapy will provide a minimally invasive paradigm for the effective treatment of solid tumors.
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U2 - 10.1021/bk-2006-0924.ch011
DO - 10.1021/bk-2006-0924.ch011
M3 - Conference contribution
AN - SCOPUS:36749062459
SN - 0841239185
SN - 9780841239180
T3 - ACS Symposium Series
SP - 169
EP - 185
BT - Polymeric Drug Delivery II Polymeric Matrices and Drug Particle Engineering
PB - American Chemical Society
ER -