Development and retrospective validation of the juvenile spondyloarthritis disease activity index

Pamela F. Weiss, Robert A. Colbert, Rui Xiao, Chris Feudtner, Timothy Beukelman, Esi Morgan Dewitt, Ilaria Pagnini, Tracey B. Wright, Carol A. Wallace

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Results. In total, 106 physicians representing 14 countries completed the initial questionnaire. Completion rates for the subsequent questionnaires were 84%, 75%, and 77% of the original respondents. Ten items exceeded 80% consensus: arthritis, enthesitis, patient pain assessment, inflammatory markers, morning stiffness, clinical sacroiliitis, uveitis, back mobility, and patient and physician assessments of disease activity. After item analysis, 2 items were eliminated (patient and physician assessments of disease activity). Factor analysis identified 3 primary domains that explained 58% of the variance: peripheral disease, axial disease, and uveitis. The Cronbach's α coefficient was 0.66. The JSpADA had high or moderate correlations with the Juvenile Arthritis Disease Activity Score (r = 0.81), patient and physician assessments of disease activity (r = 0.70 and r = 0.66, respectively), and the Childhood Health Assessment Questionnaire (r = 0.56). The JSpADA discriminated well between subjects with active versus inactive disease (P < 0.001) and was responsive to improvement or worsening in disease activity over time (P < 0.001).

Conclusion. Using international input and consensus formation techniques, we developed and validated the first disease activity assessment for juvenile spondyloarthritis. Future studies should validate the JSpADA in a prospective multicenter cohort.

Objective. To develop and validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA) for use in clinical practice and research.

Methods. Using modified Delphi consensus techniques, 10 items were selected by participants in the international pediatric rheumatology listserv, the Childhood Arthritis and Rheumatology Research Alliance, and the listserv for the pediatric section of the American College of Rheumatology. Validation was performed in a retrospective multicenter cohort of 244 children.

Original languageEnglish (US)
Pages (from-to)1775-1782
Number of pages8
JournalArthritis Care and Research
Volume66
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Physicians
Uveitis
Rheumatology
Arthritis
Sacroiliitis
Delphi Technique
Pediatrics
Juvenile Arthritis
Pain Measurement
Research
Statistical Factor Analysis
Surveys and Questionnaires
Health

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)

Cite this

Weiss, P. F., Colbert, R. A., Xiao, R., Feudtner, C., Beukelman, T., Dewitt, E. M., ... Wallace, C. A. (2014). Development and retrospective validation of the juvenile spondyloarthritis disease activity index. Arthritis Care and Research, 66(12), 1775-1782. https://doi.org/10.1002/acr.22411

Development and retrospective validation of the juvenile spondyloarthritis disease activity index. / Weiss, Pamela F.; Colbert, Robert A.; Xiao, Rui; Feudtner, Chris; Beukelman, Timothy; Dewitt, Esi Morgan; Pagnini, Ilaria; Wright, Tracey B.; Wallace, Carol A.

In: Arthritis Care and Research, Vol. 66, No. 12, 01.12.2014, p. 1775-1782.

Research output: Contribution to journalArticle

Weiss, PF, Colbert, RA, Xiao, R, Feudtner, C, Beukelman, T, Dewitt, EM, Pagnini, I, Wright, TB & Wallace, CA 2014, 'Development and retrospective validation of the juvenile spondyloarthritis disease activity index', Arthritis Care and Research, vol. 66, no. 12, pp. 1775-1782. https://doi.org/10.1002/acr.22411
Weiss PF, Colbert RA, Xiao R, Feudtner C, Beukelman T, Dewitt EM et al. Development and retrospective validation of the juvenile spondyloarthritis disease activity index. Arthritis Care and Research. 2014 Dec 1;66(12):1775-1782. https://doi.org/10.1002/acr.22411
Weiss, Pamela F. ; Colbert, Robert A. ; Xiao, Rui ; Feudtner, Chris ; Beukelman, Timothy ; Dewitt, Esi Morgan ; Pagnini, Ilaria ; Wright, Tracey B. ; Wallace, Carol A. / Development and retrospective validation of the juvenile spondyloarthritis disease activity index. In: Arthritis Care and Research. 2014 ; Vol. 66, No. 12. pp. 1775-1782.
@article{d2d5d746dac84340be358d6e22f7d445,
title = "Development and retrospective validation of the juvenile spondyloarthritis disease activity index",
abstract = "Results. In total, 106 physicians representing 14 countries completed the initial questionnaire. Completion rates for the subsequent questionnaires were 84{\%}, 75{\%}, and 77{\%} of the original respondents. Ten items exceeded 80{\%} consensus: arthritis, enthesitis, patient pain assessment, inflammatory markers, morning stiffness, clinical sacroiliitis, uveitis, back mobility, and patient and physician assessments of disease activity. After item analysis, 2 items were eliminated (patient and physician assessments of disease activity). Factor analysis identified 3 primary domains that explained 58{\%} of the variance: peripheral disease, axial disease, and uveitis. The Cronbach's α coefficient was 0.66. The JSpADA had high or moderate correlations with the Juvenile Arthritis Disease Activity Score (r = 0.81), patient and physician assessments of disease activity (r = 0.70 and r = 0.66, respectively), and the Childhood Health Assessment Questionnaire (r = 0.56). The JSpADA discriminated well between subjects with active versus inactive disease (P < 0.001) and was responsive to improvement or worsening in disease activity over time (P < 0.001).Conclusion. Using international input and consensus formation techniques, we developed and validated the first disease activity assessment for juvenile spondyloarthritis. Future studies should validate the JSpADA in a prospective multicenter cohort.Objective. To develop and validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA) for use in clinical practice and research.Methods. Using modified Delphi consensus techniques, 10 items were selected by participants in the international pediatric rheumatology listserv, the Childhood Arthritis and Rheumatology Research Alliance, and the listserv for the pediatric section of the American College of Rheumatology. Validation was performed in a retrospective multicenter cohort of 244 children.",
author = "Weiss, {Pamela F.} and Colbert, {Robert A.} and Rui Xiao and Chris Feudtner and Timothy Beukelman and Dewitt, {Esi Morgan} and Ilaria Pagnini and Wright, {Tracey B.} and Wallace, {Carol A.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1002/acr.22411",
language = "English (US)",
volume = "66",
pages = "1775--1782",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "12",

}

TY - JOUR

T1 - Development and retrospective validation of the juvenile spondyloarthritis disease activity index

AU - Weiss, Pamela F.

AU - Colbert, Robert A.

AU - Xiao, Rui

AU - Feudtner, Chris

AU - Beukelman, Timothy

AU - Dewitt, Esi Morgan

AU - Pagnini, Ilaria

AU - Wright, Tracey B.

AU - Wallace, Carol A.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Results. In total, 106 physicians representing 14 countries completed the initial questionnaire. Completion rates for the subsequent questionnaires were 84%, 75%, and 77% of the original respondents. Ten items exceeded 80% consensus: arthritis, enthesitis, patient pain assessment, inflammatory markers, morning stiffness, clinical sacroiliitis, uveitis, back mobility, and patient and physician assessments of disease activity. After item analysis, 2 items were eliminated (patient and physician assessments of disease activity). Factor analysis identified 3 primary domains that explained 58% of the variance: peripheral disease, axial disease, and uveitis. The Cronbach's α coefficient was 0.66. The JSpADA had high or moderate correlations with the Juvenile Arthritis Disease Activity Score (r = 0.81), patient and physician assessments of disease activity (r = 0.70 and r = 0.66, respectively), and the Childhood Health Assessment Questionnaire (r = 0.56). The JSpADA discriminated well between subjects with active versus inactive disease (P < 0.001) and was responsive to improvement or worsening in disease activity over time (P < 0.001).Conclusion. Using international input and consensus formation techniques, we developed and validated the first disease activity assessment for juvenile spondyloarthritis. Future studies should validate the JSpADA in a prospective multicenter cohort.Objective. To develop and validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA) for use in clinical practice and research.Methods. Using modified Delphi consensus techniques, 10 items were selected by participants in the international pediatric rheumatology listserv, the Childhood Arthritis and Rheumatology Research Alliance, and the listserv for the pediatric section of the American College of Rheumatology. Validation was performed in a retrospective multicenter cohort of 244 children.

AB - Results. In total, 106 physicians representing 14 countries completed the initial questionnaire. Completion rates for the subsequent questionnaires were 84%, 75%, and 77% of the original respondents. Ten items exceeded 80% consensus: arthritis, enthesitis, patient pain assessment, inflammatory markers, morning stiffness, clinical sacroiliitis, uveitis, back mobility, and patient and physician assessments of disease activity. After item analysis, 2 items were eliminated (patient and physician assessments of disease activity). Factor analysis identified 3 primary domains that explained 58% of the variance: peripheral disease, axial disease, and uveitis. The Cronbach's α coefficient was 0.66. The JSpADA had high or moderate correlations with the Juvenile Arthritis Disease Activity Score (r = 0.81), patient and physician assessments of disease activity (r = 0.70 and r = 0.66, respectively), and the Childhood Health Assessment Questionnaire (r = 0.56). The JSpADA discriminated well between subjects with active versus inactive disease (P < 0.001) and was responsive to improvement or worsening in disease activity over time (P < 0.001).Conclusion. Using international input and consensus formation techniques, we developed and validated the first disease activity assessment for juvenile spondyloarthritis. Future studies should validate the JSpADA in a prospective multicenter cohort.Objective. To develop and validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA) for use in clinical practice and research.Methods. Using modified Delphi consensus techniques, 10 items were selected by participants in the international pediatric rheumatology listserv, the Childhood Arthritis and Rheumatology Research Alliance, and the listserv for the pediatric section of the American College of Rheumatology. Validation was performed in a retrospective multicenter cohort of 244 children.

UR - http://www.scopus.com/inward/record.url?scp=84912120985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84912120985&partnerID=8YFLogxK

U2 - 10.1002/acr.22411

DO - 10.1002/acr.22411

M3 - Article

VL - 66

SP - 1775

EP - 1782

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 12

ER -