Development of a mimotope-based vaccine against CD20 antigen

Meng Li, Wei Han, Quiyang Zhang, Xiaochang Xue, Zenglu Wang, Yingqi Zhang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

CD20, a B-cell-specific protein, is a primary target for immunotherapy of B-cell lymphomas. We used a mimotopes of CD20 to construct vaccines for B-cell-related disorders. The immunogenicity of the vaccines was tested in BALB/c mice. Results of this study suggest that the mimotope may be a useful tool for the construction of a functional vaccine to treat B cell-related disorders.

Original languageEnglish (US)
Pages (from-to)610-614
Number of pages5
JournalProtein and Peptide Letters
Volume14
Issue number6
DOIs
StatePublished - Jun 2007

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Keywords

  • B-cell lymphoma
  • CD20
  • Immunotherapy
  • Keyhole limpet hemocyanin (KLH)
  • Mimotope
  • Vaccine

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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