Development of a new control strategy for 3D MRI-controlled interstitial ultrasound cancer therapy

Amin Yazdanpanah Goharrizi, William Apoutou N'Djin, Raymond Kwong, Rajiv Chopra

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: MRI-controlled interstitial ultrasound therapy is being developed as a minimally invasive, image-guided treatment for localized cancers. The method uses an interstitial multielement ultrasound applicator to deliver high-intensity ultrasound energy to tissue in order to achieve thermal coagulation in a target volume. Methods: A new temperature feedback control algorithm incorporating a proportional-integral controller is introduced to tackle a multiple-input single-output control problem arising in MRI-controlled interstitial ultrasound cancer therapy. The inputs to the controller block are the frequency, rotation rate, and applied power of an interstitial applicator and the output is the boundary temperature during treatment. Multiplanar magnetic resonance (MR) thermometry is acquired continuously during heating and used in the feedback control algorithm to achieve spatial control over treatment. Results: The method has been evaluated for prostate cancer treatment as an initial clinical application. Spatial treatment accuracy of a few millimeters is demonstrated in both simulations and experiments with the new controller. The spatial treatment accuracy of the new algorithm is shown to be equivalent or slightly improved over the existing approach implemented for this technology; however, the implementation of the new algorithm is much simpler, and does not involve time-intensive tuning of gain constants. Conclusions: The study demonstrates the potential advantages of a new automatic temperature control system adapted to image guided interstitial ultrasound therapy.

Original languageEnglish (US)
Article number033301
JournalMedical Physics
Volume40
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Temperature
Neoplasms
Thermometry
Therapeutics
Heating
Prostatic Neoplasms
Magnetic Resonance Spectroscopy
Hot Temperature
Technology

Keywords

  • feedback control
  • image-guided therapy
  • magnetic resonance imaging (MRI)
  • minimally invasive
  • ultrasound interstitial thermal therapy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Development of a new control strategy for 3D MRI-controlled interstitial ultrasound cancer therapy. / Goharrizi, Amin Yazdanpanah; N'Djin, William Apoutou; Kwong, Raymond; Chopra, Rajiv.

In: Medical Physics, Vol. 40, No. 3, 033301, 03.2013.

Research output: Contribution to journalArticle

Goharrizi, Amin Yazdanpanah ; N'Djin, William Apoutou ; Kwong, Raymond ; Chopra, Rajiv. / Development of a new control strategy for 3D MRI-controlled interstitial ultrasound cancer therapy. In: Medical Physics. 2013 ; Vol. 40, No. 3.
@article{e171cd6e7a2c40fa93eb84e28804230e,
title = "Development of a new control strategy for 3D MRI-controlled interstitial ultrasound cancer therapy",
abstract = "Purpose: MRI-controlled interstitial ultrasound therapy is being developed as a minimally invasive, image-guided treatment for localized cancers. The method uses an interstitial multielement ultrasound applicator to deliver high-intensity ultrasound energy to tissue in order to achieve thermal coagulation in a target volume. Methods: A new temperature feedback control algorithm incorporating a proportional-integral controller is introduced to tackle a multiple-input single-output control problem arising in MRI-controlled interstitial ultrasound cancer therapy. The inputs to the controller block are the frequency, rotation rate, and applied power of an interstitial applicator and the output is the boundary temperature during treatment. Multiplanar magnetic resonance (MR) thermometry is acquired continuously during heating and used in the feedback control algorithm to achieve spatial control over treatment. Results: The method has been evaluated for prostate cancer treatment as an initial clinical application. Spatial treatment accuracy of a few millimeters is demonstrated in both simulations and experiments with the new controller. The spatial treatment accuracy of the new algorithm is shown to be equivalent or slightly improved over the existing approach implemented for this technology; however, the implementation of the new algorithm is much simpler, and does not involve time-intensive tuning of gain constants. Conclusions: The study demonstrates the potential advantages of a new automatic temperature control system adapted to image guided interstitial ultrasound therapy.",
keywords = "feedback control, image-guided therapy, magnetic resonance imaging (MRI), minimally invasive, ultrasound interstitial thermal therapy",
author = "Goharrizi, {Amin Yazdanpanah} and N'Djin, {William Apoutou} and Raymond Kwong and Rajiv Chopra",
year = "2013",
month = "3",
doi = "10.1118/1.4793261",
language = "English (US)",
volume = "40",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "3",

}

TY - JOUR

T1 - Development of a new control strategy for 3D MRI-controlled interstitial ultrasound cancer therapy

AU - Goharrizi, Amin Yazdanpanah

AU - N'Djin, William Apoutou

AU - Kwong, Raymond

AU - Chopra, Rajiv

PY - 2013/3

Y1 - 2013/3

N2 - Purpose: MRI-controlled interstitial ultrasound therapy is being developed as a minimally invasive, image-guided treatment for localized cancers. The method uses an interstitial multielement ultrasound applicator to deliver high-intensity ultrasound energy to tissue in order to achieve thermal coagulation in a target volume. Methods: A new temperature feedback control algorithm incorporating a proportional-integral controller is introduced to tackle a multiple-input single-output control problem arising in MRI-controlled interstitial ultrasound cancer therapy. The inputs to the controller block are the frequency, rotation rate, and applied power of an interstitial applicator and the output is the boundary temperature during treatment. Multiplanar magnetic resonance (MR) thermometry is acquired continuously during heating and used in the feedback control algorithm to achieve spatial control over treatment. Results: The method has been evaluated for prostate cancer treatment as an initial clinical application. Spatial treatment accuracy of a few millimeters is demonstrated in both simulations and experiments with the new controller. The spatial treatment accuracy of the new algorithm is shown to be equivalent or slightly improved over the existing approach implemented for this technology; however, the implementation of the new algorithm is much simpler, and does not involve time-intensive tuning of gain constants. Conclusions: The study demonstrates the potential advantages of a new automatic temperature control system adapted to image guided interstitial ultrasound therapy.

AB - Purpose: MRI-controlled interstitial ultrasound therapy is being developed as a minimally invasive, image-guided treatment for localized cancers. The method uses an interstitial multielement ultrasound applicator to deliver high-intensity ultrasound energy to tissue in order to achieve thermal coagulation in a target volume. Methods: A new temperature feedback control algorithm incorporating a proportional-integral controller is introduced to tackle a multiple-input single-output control problem arising in MRI-controlled interstitial ultrasound cancer therapy. The inputs to the controller block are the frequency, rotation rate, and applied power of an interstitial applicator and the output is the boundary temperature during treatment. Multiplanar magnetic resonance (MR) thermometry is acquired continuously during heating and used in the feedback control algorithm to achieve spatial control over treatment. Results: The method has been evaluated for prostate cancer treatment as an initial clinical application. Spatial treatment accuracy of a few millimeters is demonstrated in both simulations and experiments with the new controller. The spatial treatment accuracy of the new algorithm is shown to be equivalent or slightly improved over the existing approach implemented for this technology; however, the implementation of the new algorithm is much simpler, and does not involve time-intensive tuning of gain constants. Conclusions: The study demonstrates the potential advantages of a new automatic temperature control system adapted to image guided interstitial ultrasound therapy.

KW - feedback control

KW - image-guided therapy

KW - magnetic resonance imaging (MRI)

KW - minimally invasive

KW - ultrasound interstitial thermal therapy

UR - http://www.scopus.com/inward/record.url?scp=84874776623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874776623&partnerID=8YFLogxK

U2 - 10.1118/1.4793261

DO - 10.1118/1.4793261

M3 - Article

C2 - 23464342

AN - SCOPUS:84874776623

VL - 40

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 3

M1 - 033301

ER -