In this study, we proposed and designed a transmission mode polarized hyperspectral imaging microscope (PHSIM). The hyperspectral imaging (HSI) component is based on the snapscan with a hyperspectral camera. The HSI wavelength range is from 467-700 nm. Polarized light imaging is realized by the integration of two polarizers and two liquid crystal variable retarders (LCVR), which is capable of full Stokes polarimetric imaging. The new imaging device was tested for the detection of squamous cell carcinoma (SCC) in H&E stained oral tissue slides of 8 patients. One normal area and one cancerous area on each slide are selected to make the comparison. The preliminary results indicated that the spectral curves of the Stokes vector parameters (S0, S1, S2, S3) of the normal area on the H&E stained oral tissue slides are different from those of SCC in certain wavelength range. Further work is required to apply the new polarized hyperspectral imaging microscope to a large number of patient samples and to test the PHSIM system in different cancer types.