Development of a novel synthetic material to close abdominal wall defects

Melissa A. Cnota, Shaghayegh Aliabadi-Wahle, Ella U. Choe, Jean T. Jacob, Lewis M. Flint, John J. Ferrara

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


To compare the efficacy of a novel synthetic material (TMS-2) with polytetrafluoroethylene, polypropylene (Marlex), and primary closure of experimentally fashioned clean and contaminated abdominal wounds, 1-cm2 abdominal wall defects were created in each of the four abdominal quadrants of rats (n = 10). Patches of each material were used to repair three of these defects, the fourth being primarily closed. A second group of rats (n = 7) underwent the same operative protocol; however, peritonitis was induced at the time of surgery using a fecal inoculation technique. Animals were killed 2 weeks later, and surface area and severity of formed adhesions were assessed by a 'blinded' observer. All closure techniques were successful insofar as none demonstrated fascial dehiscence. Compared with each synthetic material, the surface area of formed adhesions was smaller after primary closure in clean and in contaminated conditions; however, the three synthetic materials were equally matched regarding surface area of adhesions under both conditions. In the face of fecal contamination, TMS-2 proved identical to primary closure, each generating significantly (P < 0.02) milder adhesions than the other prosthetic materials. It is concluded that the TMS-2 may prove of clinical benefit to repair abdominal wall defects.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalAmerican Surgeon
Issue number5
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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