Development of a PET detector system compatible with MRI/NMR systems

Y. Shao; S. R. Cherry; K. Farahani; R. Slates; R. W. Silverman; K. Meadors; A. Bowery; S. Siegel; P. K. Marsden; P. B. Garlick

doi:10.1109/23.596982

Development of a PET detector system compatible with MRI/NMR systems

Y. Shao, S. R. Cherry, K. Farahani, R. Slates, R. W. Silverman, K. Meadors, A. Bowery, S. Siegel, P. K. Marsden, P. B. Garlick

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

We report the development of a prototype positron emission tomography (PET) scanner compatible with clinical magnetic resonance imaging (MRI) scanners and nuclear magnetic resonance (NMR) spectrometers. This single slice PET system consists of 72 2x2x5 mm lutetium oxyorthosilicate (LSO) crystals coupled by 2 mm diameter, 4 meter long double clad optical fibers to three multi-channel photomultiplier tubes (MC-PMT's) shielded inside an aluminum closure. The ring diameter is 54 mm and the slice thickness is ~1 mm FWHM. Measurements with a point source demonstrate that this PET system has a reconstructed resolution of 2.1 mm, a coincidence time resolution of 26 ns and a typical energy resolution of 45%. Simultaneously acquired PET and MR phantom images show no significant artifacts or distortions. We also obtained simultaneous NMR spectra and PET images from an isolated, perfused rat heart, demonstrating the power of obtaining temporally correlated PET and NMR information in biological systems. Again, no artifacts in the PET or NMR data were apparent, despite the high field strength of 9.4T. The challenge for the future is to scale up the design to develop a high resolution, high sensitivity device that can be used in simultaneous PET and MR studies of in vivo systems.

Original language	English (US)
Pages (from-to)	1167-1171
Number of pages	5
Journal	IEEE Transactions on Nuclear Science
Volume	44
Issue number	3 PART 2
DOIs	https://doi.org/10.1109/23.596982
State	Published - 1997

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

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10.1109/23.596982

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@article{a8e2b553719b43bab7d24fd04a738c80,

title = "Development of a PET detector system compatible with MRI/NMR systems",

abstract = "We report the development of a prototype positron emission tomography (PET) scanner compatible with clinical magnetic resonance imaging (MRI) scanners and nuclear magnetic resonance (NMR) spectrometers. This single slice PET system consists of 72 2x2x5 mm lutetium oxyorthosilicate (LSO) crystals coupled by 2 mm diameter, 4 meter long double clad optical fibers to three multi-channel photomultiplier tubes (MC-PMT's) shielded inside an aluminum closure. The ring diameter is 54 mm and the slice thickness is ~1 mm FWHM. Measurements with a point source demonstrate that this PET system has a reconstructed resolution of 2.1 mm, a coincidence time resolution of 26 ns and a typical energy resolution of 45%. Simultaneously acquired PET and MR phantom images show no significant artifacts or distortions. We also obtained simultaneous NMR spectra and PET images from an isolated, perfused rat heart, demonstrating the power of obtaining temporally correlated PET and NMR information in biological systems. Again, no artifacts in the PET or NMR data were apparent, despite the high field strength of 9.4T. The challenge for the future is to scale up the design to develop a high resolution, high sensitivity device that can be used in simultaneous PET and MR studies of in vivo systems.",

author = "Y. Shao and Cherry, {S. R.} and K. Farahani and R. Slates and Silverman, {R. W.} and K. Meadors and A. Bowery and S. Siegel and Marsden, {P. K.} and Garlick, {P. B.}",

note = "Funding Information: VII. ACKNOWLEDGMENTS We gratefully acknowledge the assistance of A.C. Cave, and H.G. Parkes at UMDS. This work was supported at UCLA by a pilot research grant from the Education and Research Foundation of the Society of Nuclear Medicine and by DOE contract DE-FC03-87-ER60615, and at UMDS by The Wellcome Trust (Grant #040429) and The Special Trustees of Guy's Hospital. We would like to thank the staff of the PET center and cyclotron units at UCLA and UMDS for providing isotopes for this study.",

year = "1997",

doi = "10.1109/23.596982",

language = "English (US)",

volume = "44",

pages = "1167--1171",

journal = "IEEE Transactions on Nuclear Science",

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publisher = "Institute of Electrical and Electronics Engineers Inc.",

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T1 - Development of a PET detector system compatible with MRI/NMR systems

AU - Shao, Y.

AU - Cherry, S. R.

AU - Farahani, K.

AU - Slates, R.

AU - Silverman, R. W.

AU - Meadors, K.

AU - Bowery, A.

AU - Siegel, S.

AU - Marsden, P. K.

AU - Garlick, P. B.

N1 - Funding Information: VII. ACKNOWLEDGMENTS We gratefully acknowledge the assistance of A.C. Cave, and H.G. Parkes at UMDS. This work was supported at UCLA by a pilot research grant from the Education and Research Foundation of the Society of Nuclear Medicine and by DOE contract DE-FC03-87-ER60615, and at UMDS by The Wellcome Trust (Grant #040429) and The Special Trustees of Guy's Hospital. We would like to thank the staff of the PET center and cyclotron units at UCLA and UMDS for providing isotopes for this study.

PY - 1997

Y1 - 1997

N2 - We report the development of a prototype positron emission tomography (PET) scanner compatible with clinical magnetic resonance imaging (MRI) scanners and nuclear magnetic resonance (NMR) spectrometers. This single slice PET system consists of 72 2x2x5 mm lutetium oxyorthosilicate (LSO) crystals coupled by 2 mm diameter, 4 meter long double clad optical fibers to three multi-channel photomultiplier tubes (MC-PMT's) shielded inside an aluminum closure. The ring diameter is 54 mm and the slice thickness is ~1 mm FWHM. Measurements with a point source demonstrate that this PET system has a reconstructed resolution of 2.1 mm, a coincidence time resolution of 26 ns and a typical energy resolution of 45%. Simultaneously acquired PET and MR phantom images show no significant artifacts or distortions. We also obtained simultaneous NMR spectra and PET images from an isolated, perfused rat heart, demonstrating the power of obtaining temporally correlated PET and NMR information in biological systems. Again, no artifacts in the PET or NMR data were apparent, despite the high field strength of 9.4T. The challenge for the future is to scale up the design to develop a high resolution, high sensitivity device that can be used in simultaneous PET and MR studies of in vivo systems.

AB - We report the development of a prototype positron emission tomography (PET) scanner compatible with clinical magnetic resonance imaging (MRI) scanners and nuclear magnetic resonance (NMR) spectrometers. This single slice PET system consists of 72 2x2x5 mm lutetium oxyorthosilicate (LSO) crystals coupled by 2 mm diameter, 4 meter long double clad optical fibers to three multi-channel photomultiplier tubes (MC-PMT's) shielded inside an aluminum closure. The ring diameter is 54 mm and the slice thickness is ~1 mm FWHM. Measurements with a point source demonstrate that this PET system has a reconstructed resolution of 2.1 mm, a coincidence time resolution of 26 ns and a typical energy resolution of 45%. Simultaneously acquired PET and MR phantom images show no significant artifacts or distortions. We also obtained simultaneous NMR spectra and PET images from an isolated, perfused rat heart, demonstrating the power of obtaining temporally correlated PET and NMR information in biological systems. Again, no artifacts in the PET or NMR data were apparent, despite the high field strength of 9.4T. The challenge for the future is to scale up the design to develop a high resolution, high sensitivity device that can be used in simultaneous PET and MR studies of in vivo systems.

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JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 3 PART 2

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Development of a PET detector system compatible with MRI/NMR systems

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