Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Jacinth Naidoo, Christopher J. Bemben, Shawn R. Allwein, Jue Liang, Andrew A. Pieper, Joseph M. Ready

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.

Original languageEnglish (US)
Pages (from-to)4429-4431
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number33
DOIs
StatePublished - Aug 14 2013

Keywords

  • Carbazole
  • Fluorination
  • Neuroprotective
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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