Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Jacinth Naidoo, Christopher J. Bemben, Shawn R. Allwein, Jue Liang, Andrew A. Pieper, Joseph M. Ready

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.

Original languageEnglish (US)
Pages (from-to)4429-4431
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number33
DOIs
StatePublished - Aug 14 2013

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Neuroprotective Agents
Primates
Rodentia
Purification

Keywords

  • Carbazole
  • Fluorination
  • Neuroprotective
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent. / Naidoo, Jacinth; Bemben, Christopher J.; Allwein, Shawn R.; Liang, Jue; Pieper, Andrew A.; Ready, Joseph M.

In: Tetrahedron Letters, Vol. 54, No. 33, 14.08.2013, p. 4429-4431.

Research output: Contribution to journalArticle

Naidoo, Jacinth ; Bemben, Christopher J. ; Allwein, Shawn R. ; Liang, Jue ; Pieper, Andrew A. ; Ready, Joseph M. / Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent. In: Tetrahedron Letters. 2013 ; Vol. 54, No. 33. pp. 4429-4431.
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