Development of cationic polymer coatings to regulate foreign-body responses

Minglin Ma, Wendy F. Liu, Paulina S. Hill, Kaitlin M. Bratlie, Daniel J. Siegwart, Justin Chin, Miri Park, Joao Guerreiro, Daniel G. Anderson

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

A library of cationic polymers, poly(beta-amino alcohols) with a great chemical diversity are synthesized using combinatorial polymerization. These polymers, when immobilized on a surface, drastically affect the behavior of monocyte/macrophage cells in vitro and early inflammatory reactions in vivo. Certain polymers are found capable of mitigating the foreign-body responses.

Original languageEnglish (US)
Pages (from-to)H189-H194
JournalAdvanced Materials
Volume23
Issue number24
DOIs
StatePublished - Jun 24 2011

Keywords

  • biomaterials
  • biomedical materials
  • foreign-body responses
  • poly(beta-amino alcohol)
  • polymer coatings

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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