Development of chitosan-guar gum semi-interpenetrating polymer network microspheres for controlled release of cefadroxil

K. Mallikarjuna Reddy, V. Ramesh Babu, M. Sairam, M. C S Subha, N. N. Mallikarjuna, P. V. Kulkarni, T. M. Aminabhavi

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16 Scopus citations

Abstract

Blend microspheres of chitosan (CS) and guar gum (GG) have been prepared using the water-in-oil (w/o) emulsion method. Cefadroxil was loaded into the microspheres and cross-linked with glutaraldehyde, leading to the formation of a semi-interpenetrating polymer network (IPN) structure. The microspheres have been characterized by scanning electron microscopy. X-ray diffraction and differential scanning calorimetry. Scanning electron micrographs showed the formation of non-uniform microspheres with the rough surface. X-ray diffraction and differential scanning calorimetry studies of the plain and the drug-loaded microspheres indicated that drug is dispersed at the molecular level in the semi-IPN matrix. In vitro dissolution experiments performed in pH 7.4 buffer medium indicated a sustained and controlled release of cefadroxil from semi-IPN microspheres up to 10 h. The amount of drug loaded into microspheres, CS-GG composition of the blend and the amount of cross-linking agent used have shown dependencies on the release of cefadroxil from the semi-IPN microspheres.

Original languageEnglish (US)
Pages (from-to)491-501
Number of pages11
JournalDesigned Monomers and Polymers
Volume9
Issue number5
DOIs
StatePublished - Nov 7 2006

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Keywords

  • Chitosan
  • Controlled release
  • Guar gum
  • Semi-IPN

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Reddy, K. M., Babu, V. R., Sairam, M., Subha, M. C. S., Mallikarjuna, N. N., Kulkarni, P. V., & Aminabhavi, T. M. (2006). Development of chitosan-guar gum semi-interpenetrating polymer network microspheres for controlled release of cefadroxil. Designed Monomers and Polymers, 9(5), 491-501. https://doi.org/10.1163/156855506778538047