Development of cholinergic neurons in the septal/diagonal band complex of the rat.

D. M. Armstrong, G. Bruce, L. B. Hersh, F. H. Gage

Research output: Contribution to journalArticle

Abstract

In the present study we employed immunohistochemical techniques using a polyclonal antibody against choline acetyltransferase (ChAT) to determine the distribution and cytological features of cholinergic neurons in the developing septal/diagonal band complex of the rat. ChAT-positive perikarya were first clearly detected in this region on embryonic day 17, although the neurons were faintly labeled and lacked the cytological details found in the adult. After birth we observed a dramatic increase in the intensity of the immunolabeling which continued until postnatal day 23. Thereafter, the ChAT-positive neurons assumed their adult-like characteristics.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalBrain Research
Volume433
Issue number2
StatePublished - Dec 1 1987

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Cholinergic Neurons
Choline O-Acetyltransferase
Neurons
Parturition
Antibodies

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Armstrong, D. M., Bruce, G., Hersh, L. B., & Gage, F. H. (1987). Development of cholinergic neurons in the septal/diagonal band complex of the rat. Brain Research, 433(2), 249-256.

Development of cholinergic neurons in the septal/diagonal band complex of the rat. / Armstrong, D. M.; Bruce, G.; Hersh, L. B.; Gage, F. H.

In: Brain Research, Vol. 433, No. 2, 01.12.1987, p. 249-256.

Research output: Contribution to journalArticle

Armstrong, DM, Bruce, G, Hersh, LB & Gage, FH 1987, 'Development of cholinergic neurons in the septal/diagonal band complex of the rat.', Brain Research, vol. 433, no. 2, pp. 249-256.
Armstrong, D. M. ; Bruce, G. ; Hersh, L. B. ; Gage, F. H. / Development of cholinergic neurons in the septal/diagonal band complex of the rat. In: Brain Research. 1987 ; Vol. 433, No. 2. pp. 249-256.
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