Developmental and extrahepatic physiological functions of SREBP pathway genes in mice

Luke J. Engelking, Mary Jo Cantoria, Yanchao Xu, Guosheng Liang

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Sterol regulatory element-binding proteins (SREBPs), master transcriptional regulators of cholesterol and fatty acid synthesis, have been found to contribute to a diverse array of cellular processes. In this review, we focus on genetically engineered mice in which the activities of six components of the SREBP gene pathway, namely SREBP-1, SREBP-2, Scap, Insig-1, Insig-2, or Site-1 protease have been altered through gene knockout or transgenic approaches. In addition to the expected impacts on lipid metabolism, manipulation of these genes in mice is found to affect a wide array of developmental and physiologic processes ranging from interferon signaling in macrophages to synaptic transmission in the brain. The findings reviewed herein provide a blueprint to guide future studies defining the complex interactions between lipid biology and the physiologic processes of many distinct organ systems.

Original languageEnglish (US)
Pages (from-to)98-109
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume81
DOIs
StatePublished - Sep 2018

Keywords

  • Biosynthesis
  • Cholesterol
  • Gene expression
  • Knockout
  • Lipid
  • SREBP

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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