Developmental and extrahepatic physiological functions of SREBP pathway genes in mice

Luke J. Engelking, Mary Jo Cantoria, Yanchao Xu, Guosheng Liang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Sterol regulatory element-binding proteins (SREBPs), master transcriptional regulators of cholesterol and fatty acid synthesis, have been found to contribute to a diverse array of cellular processes. In this review, we focus on genetically engineered mice in which the activities of six components of the SREBP gene pathway, namely SREBP-1, SREBP-2, Scap, Insig-1, Insig-2, or Site-1 protease have been altered through gene knockout or transgenic approaches. In addition to the expected impacts on lipid metabolism, manipulation of these genes in mice is found to affect a wide array of developmental and physiologic processes ranging from interferon signaling in macrophages to synaptic transmission in the brain. The findings reviewed herein provide a blueprint to guide future studies defining the complex interactions between lipid biology and the physiologic processes of many distinct organ systems.

Original languageEnglish (US)
JournalSeminars in Cell and Developmental Biology
DOIs
StateAccepted/In press - 2017

Keywords

  • Biosynthesis
  • Cholesterol
  • Gene expression
  • Knockout
  • Lipid
  • SREBP

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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