Developmental and extrahepatic physiological functions of SREBP pathway genes in mice

Luke J. Engelking, Mary Jo Cantoria, Yanchao Xu, Guosheng Liang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sterol regulatory element-binding proteins (SREBPs), master transcriptional regulators of cholesterol and fatty acid synthesis, have been found to contribute to a diverse array of cellular processes. In this review, we focus on genetically engineered mice in which the activities of six components of the SREBP gene pathway, namely SREBP-1, SREBP-2, Scap, Insig-1, Insig-2, or Site-1 protease have been altered through gene knockout or transgenic approaches. In addition to the expected impacts on lipid metabolism, manipulation of these genes in mice is found to affect a wide array of developmental and physiologic processes ranging from interferon signaling in macrophages to synaptic transmission in the brain. The findings reviewed herein provide a blueprint to guide future studies defining the complex interactions between lipid biology and the physiologic processes of many distinct organ systems.

Original languageEnglish (US)
JournalSeminars in Cell and Developmental Biology
DOIs
StateAccepted/In press - 2017

Fingerprint

Sterol Regulatory Element Binding Proteins
Sterol Regulatory Element Binding Protein 2
Sterol Regulatory Element Binding Protein 1
Gene Knockout Techniques
Lipid Metabolism
Synaptic Transmission
Interferons
Genes
Fatty Acids
Macrophages
Cholesterol
Lipids
Brain

Keywords

  • Biosynthesis
  • Cholesterol
  • Gene expression
  • Knockout
  • Lipid
  • SREBP

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

@article{5c57b844c24e445ca0bd429a2b26a56f,
title = "Developmental and extrahepatic physiological functions of SREBP pathway genes in mice",
abstract = "Sterol regulatory element-binding proteins (SREBPs), master transcriptional regulators of cholesterol and fatty acid synthesis, have been found to contribute to a diverse array of cellular processes. In this review, we focus on genetically engineered mice in which the activities of six components of the SREBP gene pathway, namely SREBP-1, SREBP-2, Scap, Insig-1, Insig-2, or Site-1 protease have been altered through gene knockout or transgenic approaches. In addition to the expected impacts on lipid metabolism, manipulation of these genes in mice is found to affect a wide array of developmental and physiologic processes ranging from interferon signaling in macrophages to synaptic transmission in the brain. The findings reviewed herein provide a blueprint to guide future studies defining the complex interactions between lipid biology and the physiologic processes of many distinct organ systems.",
keywords = "Biosynthesis, Cholesterol, Gene expression, Knockout, Lipid, SREBP",
author = "Engelking, {Luke J.} and Cantoria, {Mary Jo} and Yanchao Xu and Guosheng Liang",
year = "2017",
doi = "10.1016/j.semcdb.2017.07.011",
language = "English (US)",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Developmental and extrahepatic physiological functions of SREBP pathway genes in mice

AU - Engelking, Luke J.

AU - Cantoria, Mary Jo

AU - Xu, Yanchao

AU - Liang, Guosheng

PY - 2017

Y1 - 2017

N2 - Sterol regulatory element-binding proteins (SREBPs), master transcriptional regulators of cholesterol and fatty acid synthesis, have been found to contribute to a diverse array of cellular processes. In this review, we focus on genetically engineered mice in which the activities of six components of the SREBP gene pathway, namely SREBP-1, SREBP-2, Scap, Insig-1, Insig-2, or Site-1 protease have been altered through gene knockout or transgenic approaches. In addition to the expected impacts on lipid metabolism, manipulation of these genes in mice is found to affect a wide array of developmental and physiologic processes ranging from interferon signaling in macrophages to synaptic transmission in the brain. The findings reviewed herein provide a blueprint to guide future studies defining the complex interactions between lipid biology and the physiologic processes of many distinct organ systems.

AB - Sterol regulatory element-binding proteins (SREBPs), master transcriptional regulators of cholesterol and fatty acid synthesis, have been found to contribute to a diverse array of cellular processes. In this review, we focus on genetically engineered mice in which the activities of six components of the SREBP gene pathway, namely SREBP-1, SREBP-2, Scap, Insig-1, Insig-2, or Site-1 protease have been altered through gene knockout or transgenic approaches. In addition to the expected impacts on lipid metabolism, manipulation of these genes in mice is found to affect a wide array of developmental and physiologic processes ranging from interferon signaling in macrophages to synaptic transmission in the brain. The findings reviewed herein provide a blueprint to guide future studies defining the complex interactions between lipid biology and the physiologic processes of many distinct organ systems.

KW - Biosynthesis

KW - Cholesterol

KW - Gene expression

KW - Knockout

KW - Lipid

KW - SREBP

UR - http://www.scopus.com/inward/record.url?scp=85026322800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026322800&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2017.07.011

DO - 10.1016/j.semcdb.2017.07.011

M3 - Article

C2 - 28736205

AN - SCOPUS:85026322800

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -