Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system

Ioanna Kotsopoulou, Arpita K. Vyas, Melinda J. Cory, Christina S. Chan, Jawahar Jagarapu, Shamaila Gill, Manjula Mudduluru, Dimitrios Angelis

Research output: Contribution to journalReview articlepeer-review

Abstract

Thyroid hormones play an important role in the development and function of the cardiac myocyte. Dysregulation of the thyroid hormone milieu affects the fetal cardiac cells via complex molecular mechanisms, either by altering gene expression or directly by affecting post-translational processes. This review offers a comprehensive summary of the effects of thyroid hormones on the developing cardiovascular system and its adaptation. Furthermore, we will highlight the gaps in knowledge and provide suggestions for future research.

Original languageEnglish (US)
Pages (from-to)1576-1586
Number of pages11
JournalJournal of Perinatology
Volume42
Issue number12
DOIs
StatePublished - Dec 2022

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint

Dive into the research topics of 'Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system'. Together they form a unique fingerprint.

Cite this